K
Kohji Akimoto
Researcher at Keio University
Publications - 21
Citations - 1455
Kohji Akimoto is an academic researcher from Keio University. The author has contributed to research in topics: Total synthesis & Neamine. The author has an hindex of 13, co-authored 21 publications receiving 1394 citations.
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Journal ArticleDOI
Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice
Masahiro Morita,Kazuhiro Motoki,Kohji Akimoto,Takenori Natori,Teruyuki Sakai,Eiji Sawa,Kazuo Yamaji,Yasuhiko Koezuka,Eiichi Kobayashi,Hideaki Fukushima +9 more
TL;DR: KRN7000, (2S,3S,4R)-1-O-(alpha-D- galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol, was selected as a candidate for clinical application.
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Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus
TL;DR: New glycosphingolipids, named agelasphins, have been isolated by antitumor and immunostimulatory bioassay-guided purification from an extract of a marine sponge, Agelas mauritianus.
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Enantiodivergent total syntheses of nanaomycins and their enantiomers, kalafungins
TL;DR: The first enantiospecific total syntheses of pyranonaphthoquinone antibiotics, nanaomycins D and A, and their enantiomers, kalafungin and 4-deoxykalafinic acid are described by an enantiodivergent strategy from a common optically active intermediate, (1S,3RS,4S)-3,4-dihydro-5,9,10-trimethoxy-1-methyl-1H-naphthoe[2,3-c
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Immunostimulatory and Antitumor Activities of Monoglycosylceramides Having Various Sugar Moieties
Kazuhiro Motoki,Masahiro Morita,Eiichi Kobayashi,Takeshi Uchida,Kohji Akimoto,Hideaki Fukushima,Yasuhiko Koezuka +6 more
TL;DR: The manner of combination between sugar and ceramide has been demonstrated to affect the manifestation of immunostimulatory and resultant antitumor activities of MonoCers, and in the case of D-MonoCers having the D-sugar, alpha-D-MonOCers show stronger activities than beta-D.