K
Kojiro Kimura
Researcher at American Board of Legal Medicine
Publications - 28
Citations - 1393
Kojiro Kimura is an academic researcher from American Board of Legal Medicine. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 16, co-authored 27 publications receiving 1336 citations.
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Identification of the heme compound copurified with deoxyribonucleic acid (DNA) from bloodstains, a major inhibitor of polymerase chain reaction (PCR) amplification.
TL;DR: The heme compound found in deoxyribonucleic acid (DNA) extracted from bloodstains, which is regarded as a major inhibitor of polymerase chain reaction (PCR), was characterized in comparison with alkaline and acid hematin, histidine and ammonia hemochromogens, and globin and serum albumin hemochROMogens digested by proteinase K.
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Carrier-mediated processes in blood–brain barrier penetration and neural uptake of paraquat
Keiko Shimizu,Ko-ichi Ohtaki,Kazuo Matsubara,Koji Aoyama,Takashi Uezono,Osamu Saito,Manabu Suno,Kento Ogawa,Nobumasa Hayase,Kojiro Kimura,Hiroshi Shiono +10 more
TL;DR: Findings indicated that paraquat is possibly taken up into the brain by the neutral amino acid transport system, then transported into striatal, possibly neuronal, cells in a Na(+)-dependent manner.
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Endogenously Occurring β‐Carboline Induces Parkinsonism in Nonprimate Animals: A Possible Causative Protoxin in Idiopathic Parkinson's Disease
Kazuo Matsubara,Tatsuo Gonda,Hideyuki Sawada,Takashi Uezono,Yuta Kobayashi,Takashi Kawamura,Ko-ichi Ohtaki,Kojiro Kimura,Akinori Akaike +8 more
TL;DR: Results indicated that 9‐indole nitrogen methylation should be the limiting step in the development of the toxicity of NH, a selective dopaminergic toxin precursor, which could be an underlying factor in idiopathic Parkinson's disease.
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Reduced dorsal hippocampal glutamate release significantly correlates with the spatial memory deficits produced by benzodiazepines and ethanol
TL;DR: The present results strongly indicated that presynaptic dysfunction in dorsal hippocampal glutamatergic neurons would be critical for spatial memory deficits induced by benzodiazepines and ethanol.
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Simultaneous determination of nicotine and cotinine in various human tissues using capillary gas chromatography/mass spectrometry.
TL;DR: S skeletal muscle is, therefore, considered to be the most suitable tissue sample for toxicological examination, when acquisition of blood samples is not feasible, and the tissue/blood concentration ratios of nicotine and cotinine were most stable in skeletal muscle.