H
Hiroshi Shiono
Researcher at Asahikawa Medical College
Publications - 91
Citations - 2120
Hiroshi Shiono is an academic researcher from Asahikawa Medical College. The author has contributed to research in topics: Dermatoglyphics & Poison control. The author has an hindex of 22, co-authored 90 publications receiving 2044 citations. Previous affiliations of Hiroshi Shiono include American Board of Legal Medicine.
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Journal ArticleDOI
Carrier-mediated processes in blood–brain barrier penetration and neural uptake of paraquat
Keiko Shimizu,Ko-ichi Ohtaki,Kazuo Matsubara,Koji Aoyama,Takashi Uezono,Osamu Saito,Manabu Suno,Kento Ogawa,Nobumasa Hayase,Kojiro Kimura,Hiroshi Shiono +10 more
TL;DR: Findings indicated that paraquat is possibly taken up into the brain by the neutral amino acid transport system, then transported into striatal, possibly neuronal, cells in a Na(+)-dependent manner.
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Pralidoxime Iodide (2-PAM) Penetrates Across the Blood-Brain Barrier
Koichi Sakurada,Kazuo Matsubara,Keiko Shimizu,Hiroshi Shiono,Yasuo Seto,Koichiro Tsuge,Mineo Yoshino,Ikuko Sakai,Harutaka Mukoyama,Takehiko Takatori +9 more
TL;DR: The in vivo rat brain microdialysis technique with HPLC/UV was used to determine the blood-brain barrier penetration of pralidoxime iodide, indicating the intravenous administration of 2-PAM might be to a degree effective to reactivation of the blocked cholinesterase in the brain.
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Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats
TL;DR: The constant exposure to low levels of paraquat may lead to the vulnerability of dopamine terminals in humans, and might potentiate neurodegeneration caused by the exposure of other substances, such as endogenous dopaminergic toxins.
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Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases.
Koji Aoyama,Kazuo Matsubara,Yasunori Fujikawa,Yukio Nagahiro,Keiko Shimizu,Nobuyuki Umegae,Nobumasa Hayase,Hiroshi Shiono,Shotai Kobayashi +8 more
TL;DR: The nitrated Mn‐SOD level was strikingly elevated in amyotrophic lateral sclerosis patients and was slightly increased in Alzheimer's and Parkinson's disease patients, whereas an elevated Mn‐sod level was observed only in progressive supranuclear palsy group.
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Potential bioactivated neurotoxicants, N-methylated β-carbolinium ions, are present in human brain
Kazuo Matsubara,Michael A. Collins,Atsushi Akane,Jun Ikebuchi,Edward J. Neafsey,Masato Kagawa,Hiroshi Shiono +6 more
TL;DR: Levels of NH and HA were also significantly higher in the nigra than in the cortex, whereas 2-MeHA and 2,9-Me2HA were below detection limits, and 2[beta]-N-Methylation activity was significantly higher than 9[indole]N-methylation activity in both regions.