K
Konstantin Khrapko
Researcher at Northeastern University
Publications - 110
Citations - 6968
Konstantin Khrapko is an academic researcher from Northeastern University. The author has contributed to research in topics: Mitochondrial DNA & Point mutation. The author has an hindex of 38, co-authored 96 publications receiving 6621 citations. Previous affiliations of Konstantin Khrapko include Engelhardt Institute of Molecular Biology & Massachusetts Institute of Technology.
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A microRNA array reveals extensive regulation of microRNAs during brain development
TL;DR: It is shown that an oligonucleotide DNA array can be successfully used for the simultaneous analysis of miRNA expression profiles from tissues or cells and provided a new tool for studying mi RNA expression in a variety of biological and pathobiological settings.
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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Yevgenya Kraytsberg,Elena Kudryavtseva,Ann C. McKee,Ann C. McKee,Changiz Geula,Neil W. Kowall,Neil W. Kowall,Konstantin Khrapko +7 more
TL;DR: Using a novel single-molecule PCR approach to quantify the total burden of mitochondrial DNA molecules with deletions, it is shown that a high proportion of individual pigmented neurons in the aged human substantia nigra contain very high levels of mtDNA deletions.
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An oligonucleotide hybridization approach to DNA sequencing
Konstantin Khrapko,Yu. P. Lysov,A.A. Khorlyn,Valentin V. Shick,V. L. Florentiev,Andrei D. Mirzabekov +5 more
TL;DR: DNA sequencing; Oligonucleotide hybridization, immobilized
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High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection
Hilary A. Coller,Konstantin Khrapko,Natalya Bodyak,Ekaterina Nekhaeva,Pablo Herrero-Jimenez,William G. Thilly +5 more
TL;DR: Through extensive computer modeling, it is demonstrated that there is sufficient opportunity for a tumor progenitor cell to achieve homoplasmy through unbiased mtDNA replication and sorting during cell division, and random processes are sufficient to explain the incidence of homoplasmic mtDNA mutations in human tumors.
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Recombination of Human Mitochondrial DNA
Yevgenya Kraytsberg,Marianne Schwartz,Timothy A. Brown,Konstantin Ebralidse,Wolfram S. Kunz,David A. Clayton,John Vissing,Konstantin Khrapko +7 more
TL;DR: Human mitochondrial DNA is a 16.5-kb, circular genome essential for the maintenance of mitochondrial function and is present in multiple copies in most cell types and makes mtDNA useful in tracing human lineages.