K
Konstantin Leskov
Researcher at Case Western Reserve University
Publications - 33
Citations - 2433
Konstantin Leskov is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Clusterin & DNA repair. The author has an hindex of 17, co-authored 27 publications receiving 2285 citations. Previous affiliations of Konstantin Leskov include University of Texas Southwestern Medical Center & University of Wisconsin-Madison.
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Journal ArticleDOI
Synthesis and functional analyses of nuclear clusterin, a cell death protein
TL;DR: The results indicate that an inactive precursor of nCLU exists in the cytoplasm of non-irradiated MCF-7 cells, translocates into the nucleus following IR, and induces apoptosis.
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Ku70 suppresses the apoptotic translocation of Bax to mitochondria
Motoshi Sawada,Weiyong Sun,Paulette L. Hayes,Konstantin Leskov,David A. Boothman,Shigemi Matsuyama +5 more
TL;DR: Results suggest that in addition to its previously recognized DNA repair activity in the nucleus, Ku70 has a cytoprotective function in the cytosol that controls the localization of Bax.
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Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer
B. Shannan,Markus Seifert,Konstantin Leskov,J. Willis,David A. Boothman,Wolfgang Tilgen,Jörg Reichrath +6 more
TL;DR: This review summarizes the present understanding of the importance of CLU in various physiological functions including tumour growth, and discusses its relevance to future cancer therapy.
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Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death
Chin-Rang Yang,Konstantin Leskov,Kelly Hosley-Eberlein,Tracy Criswell,John J. Pink,Timothy J. Kinsella,David A. Boothman +6 more
TL;DR: Enhanced expression and accumulation of nuclear CLU/XIP8-Ku70/Ku80 complexes appears to be an important cell death signal after IR exposure.
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Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation.
TL;DR: A review of the literature demonstrates that extrapolation from high doses of IR to low doses ofIR is inaccurate for most transcription factors and most IR-inducible transcripts/proteins, and that induction of transactivating proteins at low doses must be empirically derived.