K
Konstantinos Ritis
Researcher at Democritus University of Thrace
Publications - 100
Citations - 16641
Konstantinos Ritis is an academic researcher from Democritus University of Thrace. The author has contributed to research in topics: Neutrophil extracellular traps & Familial Mediterranean fever. The author has an hindex of 40, co-authored 91 publications receiving 12890 citations. Previous affiliations of Konstantinos Ritis include Umeå University.
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Journal ArticleDOI
Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome
TL;DR: Recently, rilonacept, a long-acting IL-1 receptor fusion protein, and canakinumab, a fully humanized anti-IL-1beta monoclonal antibody, have been developed, with the intention to further extent IL 1β inhibition treatment strategies to a broader spectrum of disorders beyond the characterized autoinflammatory syndromes, offering a more favorable administration profile as discussed by the authors.
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Regulation of the autophagic machinery in human neutrophils.
Ioannis Mitroulis,Ioannis Kourtzelis,Ioannis Kourtzelis,Konstantinos Kambas,Stavros Rafail,Akrivi Chrysanthopoulou,Matthaios Speletas,Konstantinos Ritis +7 more
TL;DR: Evidence is provided that autophagy is implicated in human neutrophils in both a phagocytosis‐independent (rapamycin, TLR agonists, PMA) and phagcytosis (Escherichia coli)‐dependent initiation manner and a transcriptional level of regulation for the autophagic machinery.
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Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis
Christianna Choulaki,G. Papadaki,Argyro Repa,Eleni Kampouraki,Konstantinos Kambas,Konstantinos Ritis,George Bertsias,Dimitrios T. Boumpas,Prodromos Sidiropoulos +8 more
TL;DR: Patients with active RA have increased expression of NLRP3 andNLRP3-mediated IL-1β secretion in whole blood cells upon stimulation via TLR3 and TLR4 but not TLR2.
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C5a and TNF-α Up-Regulate the Expression of Tissue Factor in Intra-Alveolar Neutrophils of Patients with the Acute Respiratory Distress Syndrome
Konstantinos Kambas,Maciej M. Markiewski,Ioannis Pneumatikos,Stavros Rafail,Vassiliki Theodorou,Dimitrios Konstantonis,Ioannis Kourtzelis,Michael Doumas,Paola Magotti,Robert A. DeAngelis,John D. Lambris,Konstantinos Ritis +11 more
TL;DR: The results confirm that the procoagulant properties of BALF from ARDS patients are the result of TF induction, and further indicate that BALF neutrophils are a main source of TF in intra-alveolar fluid.
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Neutrophils, IL-1β, and gout: is there a link?
TL;DR: The recent experimental data regarding the crosstalk between IL-1β and neutrophils in the pathogenesis of acute gout are discussed.