K
Konstantinos Sousounis
Researcher at University of Dayton
Publications - 17
Citations - 583
Konstantinos Sousounis is an academic researcher from University of Dayton. The author has contributed to research in topics: Regeneration (biology) & Lens (anatomy). The author has an hindex of 13, co-authored 16 publications receiving 497 citations. Previous affiliations of Konstantinos Sousounis include Tufts University & Baylor College of Medicine.
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Journal ArticleDOI
A de novo assembly of the newt transcriptome combined with proteomic validation identifies new protein families expressed during tissue regeneration.
Mario Looso,Jens Preussner,Konstantinos Sousounis,Marc Bruckskotten,Christian S. Michel,Ettore Lignelli,Richard Reinhardt,Sabrina Höffner,Marcus Krüger,Panagiotis A. Tsonis,Thilo Borchardt,Thomas Braun +11 more
TL;DR: It is demonstrated that the multistep assembly approach allows de novo assembly of the newt transcriptome with an annotation grade comparable to well characterized organisms.
Journal ArticleDOI
Organ repair and regeneration: an overview.
TL;DR: Organ regeneration is a promising therapy that can alleviate humans from diseases that have not been yet cured and is also superior to already existing treatments that utilize exogenous sources to substitute for the organ's lost structure and/or function(s).
Book ChapterDOI
Aging and regeneration in vertebrates.
TL;DR: Ver vertebrate regeneration declines with age with the loss of stem/progenitor cell function, and future studies on improving the function of stem cells, along with studies in fish and amphibians where regeneration does not decline with age, will undoubtedly provide insights into both processes.
Journal ArticleDOI
Transcriptome analysis of newt lens regeneration reveals distinct gradients in gene expression patterns.
Konstantinos Sousounis,Mario Looso,Nobuyasu Maki,Clifford J. Ivester,Thomas Braun,Panagiotis A. Tsonis +5 more
TL;DR: Next generation RNA-seq was employed to determine gene expression patterns during lens regeneration in Notophthalmus viridescens to provide insight into the mechanism of lens regeneration, the markers that are specific to dorsal or ventral iris, and layout a map for future studies in the field.
Journal ArticleDOI
Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotls
Donald M. Bryant,Konstantinos Sousounis,Konstantinos Sousounis,Duygu Payzin-Dogru,Sevara Bryant,Aaron Gabriel W Sandoval,Jose Martinez Fernandez,Rachelle Mariano,Rachel Oshiro,Alan Y. Wong,Nicholas D. Leigh,Kimberly Johnson,Jessica L. Whited,Jessica L. Whited +13 more
TL;DR: It is found that repeated limb amputation severely compromised axolotls’ ability to initiate limb regeneration, and results suggest that repeatedly amputated limbs may undergo a persistent wound healing response, which interferes with their ability to initiated the regenerative program.