Mario Looso

TL;DR: A framework aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibility profiles and apply it to zygotic development datasets is developed, and it is found that TOBIAS outperforms existing methods for bias correction and footprinting.

TL;DR: To investigate the role of immune responses in cardiac regeneration, delayed macrophage recruitment in zebrafish and observed compromised neovascularization, neutrophil clearance, cardiomyocyte proliferation and scar resolution, which provides further insight into the complex role of the immune response during regeneration.

TL;DR: Modulation of the activated CF population is a promising approach to prevent adverse cardiac remodeling in response to angiotensin II and after myocardial infarction.

TL;DR: Control by the histone demethylase JARID1B, MANTIS was downregulated in patients with idiopathic pulmonary arterial hypertension and in rats treated with monocrotaline, whereas it was upregulated in carotid arteries of Macaca fascicularis subjected to atherosclerosis regression diet, and in endothelial cells isolated from human glioblastoma patients.

TL;DR: It is shown that CPC fate transitions are associated with distinct open chromatin states critically depending on Isl1 and Nkx2-5, and provides a model of transcriptional and epigenetic regulations during cardiac progenitor cell fate decisions at single-cell resolution.