Kooresh I. Shoghi

TL;DR: The NCI co-clinical imaging research program (CIRP) conducted a survey to identify metadata requirements for reproducible quantitative coclinical imaging as mentioned in this paper , which has broad implications for capturing coclinical data, enabling interoperability and data sharing, as well as potentially leading to updates to the preclinical Digital Imaging and Communications in Medicine (DICOM).

TL;DR: In this paper , the authors describe the design, synthesis, characterization, and evaluation in murine AAA and human aortic tissue of a first-in-class MMP-targeted positron emission tomography radioligand, 64Cu-RYM2.

TL;DR: The development of an artificial tissue bioreactor (ATB) designed to simulate the 3D structure and microenvironment of tissues in vivo, with multiple avenues of sampling, including the tissue chamber, for downstream analysis is reported on.

TL;DR: In this paper , the PARP-1 expression in prostate cancer patients with and without HRR genomic alternations using a novel PARPbased imaging agent was assessed by immunohistochemistry (IHC).

TL;DR: In this paper, the authors exploit the heterogeneity afforded by patient-derived tumor xenografts (PDX) to optimize robust radiomic features associated with response to therapy in the context of a co-clinical trial and implement PDX-optimized image features in the corresponding clinical study to predict and assess response using machine-learning (ML) algorithms.