D
Dong Zhou
Researcher at Washington University in St. Louis
Publications - 80
Citations - 1554
Dong Zhou is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 24, co-authored 49 publications receiving 1276 citations.
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Journal ArticleDOI
Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.
Dong Zhou,Wenhua Chu,Justin Rothfuss,Chenbo Zeng,Jinbin Xu,Lynne Jones,Michael J. Welch,Robert H. Mach +7 more
TL;DR: A non-peptide-based isatin sulfonamide analog, WC-II-89, was synthesized and its inhibition toward recombinant human caspase-3 and other caspases was determined as mentioned in this paper.
Journal ArticleDOI
Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.
Wenhua Chu,Dong Zhou,Vrinda Gaba,Jialu Liu,Shihong Li,Xin Peng,Jinbin Xu,Dhruva Dhavale,Devika P. Bagchi,Andre d'Avignon,Naomi Shakerdge,Brian J. Bacskai,Zhude Tu,Paul T. Kotzbauer,Robert H. Mach,Robert H. Mach +15 more
TL;DR: The data described here provide key structural information in the design of probes which bind preferentially to α-syn versus Aβ or tau fibrils.
Journal ArticleDOI
64Cu Core-labeled nanoparticles with high specific activity via metal-free click chemistry.
Dexing Zeng,Nam S. Lee,Yongjian Liu,Dong Zhou,Carmen S. Dence,Karen L. Wooley,John A. Katzenellenbogen,Michael J. Welch +7 more
TL;DR: A novel strategy based on metal-free "click" chemistry was developed for the copper-64 radiolabeling of the core in shell-cross-linked nanoparticles (SCK-NPs), with the highest specific activity obtained for Cu-64-labeled nanoparticles.
Journal ArticleDOI
Assessment of Progesterone Receptors in Breast Carcinoma by PET with 21-18F-Fluoro-16α,17α-[(R)-(1′-α-furylmethylidene)Dioxy]-19-Norpregn-4-Ene-3,20-Dione
Farrokh Dehdashti,Richard Laforest,Feng Gao,Feng Gao,Rebecca Aft,Carmen S. Dence,Dong Zhou,Kooresh I. Shoghi,Barry A. Siegel,John A. Katzenellenbogen,Michael J. Welch +10 more
TL;DR: 18F-FFNP PET is a safe, noninvasive means for evaluating tumor PRs in vivo in patients with breast cancer, and the relatively small absorbed doses to normal organs allow for the safe injection of up to 440 MBq of 18F- FFNP.
Journal ArticleDOI
Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.
Wenhua Chu,Justin Rothfuss,Andre d'Avignon,Chenbo Zeng,Dong Zhou,Richard S. Hotchkiss,Robert H. Mach +6 more
TL;DR: A series of isatin sulfonamide analogs having a Michael acceptor were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated.