K
Kopparam Manjunath
Researcher at Kakatiya University
Publications - 10
Citations - 1453
Kopparam Manjunath is an academic researcher from Kakatiya University. The author has contributed to research in topics: Solid lipid nanoparticle & Lipid modification. The author has an hindex of 9, co-authored 9 publications receiving 1334 citations. Previous affiliations of Kopparam Manjunath include Kuvempu University.
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Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.
TL;DR: DSC and PXRD analysis showed that clozapine is dispersed in SLN in an amorphous state and the release pattern of drug is analyzed and found to follow Weibull and Higuchi equations.
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Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.
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Solid lipid nanoparticles as drug delivery systems.
TL;DR: Various lipid matrices, surfactants, and other excipients used in formulation, preparation methods, sterilization and lyophilization of SLNs are discussed in this article.
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Preparation, characterization, and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles.
TL;DR: In vitro stability studies showed the slow release and stability of lovastatin SLN, and the relative bioavailabilities of lovaston hydroxy acid of SLN were increased by ∼173% and 324%, respectively, compared with the reference Lovastatin suspension.
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Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration
TL;DR: SLN are suitable drug delivery systems for the improvement of bioavailability of nitrendipine especially in brain, heart and reticuloendothelial cells containing organs.