Journal ArticleDOI
Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.
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TLDR
DSC and PXRD analysis showed that clozapine is dispersed in SLN in an amorphous state and the release pattern of drug is analyzed and found to follow Weibull and Higuchi equations.About:
This article is published in Journal of Controlled Release.The article was published on 2004-03-24. It has received 518 citations till now. The article focuses on the topics: Lipid modification & Solid lipid nanoparticle.read more
Citations
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Journal ArticleDOI
Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles.
TL;DR: Evidence is provided that SLNs are valuable as an oral delivery carrier to enhance the absorption of a poorly water soluble drug, quercetin.
Journal ArticleDOI
Potential of solid lipid nanoparticles in brain targeting.
TL;DR: The barriers to CNS drug delivery, strategies to bypass the blood-brain barrier and characterization methods of SLNs and their usefulness are discussed.
Journal Article
Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives.
Melike Üner,Gülgün Yener +1 more
TL;DR: In this paper, the authors review types of solid lipid nanoparticles (SLN), principles of drug loading and models of drug incorporation, and the influence of PEG coating on particle size and surface characteristics.
Journal ArticleDOI
Nanoparticles: Emerging carriers for drug delivery.
TL;DR: A technology platform that provides a wide range of synthetic nanostructures that may be controlled as a function of size, shape and surface chemistry and scale to these nanotechnical dimensions will be a critical first step in developing appropriate tools and a scientific basis for understanding nanoparticles.
Journal ArticleDOI
Solid Lipid Nanoparticles as Delivery Systems for Bioactive Food Components
Jochen Weiss,Eric A. Decker,D. Julian McClements,Kristberg Kristbergsson,Thrandur Helgason,Tarek S. Awad +5 more
TL;DR: Solid lipid nanoparticles (SLN) as discussed by the authors are a type of nano-emulsions with the dispersed phase being composed of a solid carrier lipid and bioactive ingredient mixture.
References
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery – Drug release and release mechanism
TL;DR: The principle suitability of SLN as a prolonged release formulation for lipophilic drugs is demonstrated and tetracaine and prednisolone loaded SLN showed a distinctly prolonged release over a monitored period of 5 weeks.
Journal ArticleDOI
Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids.
TL;DR: The presented carrier of colloidal lipid particles with improved payloads and enhanced storage stability was investigated and adds additional benefits to the well-known opportunities of conventional SLN and is suited for topical use.
Journal ArticleDOI
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
TL;DR: A good correlation between polymorphic transitions and increased drug release was observed in this study and was often related to the metastable beta' polymorph.
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Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more