K
Kristina Michel
Publications - 1
Citations - 229
Kristina Michel is an academic researcher. The author has contributed to research in topics: Antigen & Cell. The author has an hindex of 1, co-authored 1 publications receiving 88 citations.
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An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
Katharina Reinhard,Benjamin Rengstl,Petra Oehm,Kristina Michel,Arne Billmeier,Nina Hayduk,Oliver Klein,Kathrin Kuna,Yasmina Ouchan,Stefan Wöll,Elmar Christ,David Weber,Martin Suchan,Thomas Bukur,Matthias Birtel,Veronika Jahndel,Karolina Anna Mroz,Kathleen Hobohm,Lena M. Kranz,Mustafa Diken,Klaus Kühlcke,Özlem Türeci,Ugur Sahin +22 more
TL;DR: A two-part “CARVac” strategy to overcome poor CAR-T cell stimulation and responses in vivo is described and a nanoparticulate RNA vaccine, designed for body-wide delivery of the CAR antigen into lymphoid compartments, stimulates adoptively transferredCAR-T cells.