N
Nina Hayduk
Publications - 3
Citations - 255
Nina Hayduk is an academic researcher. The author has contributed to research in topics: Antigen & Cell. The author has an hindex of 2, co-authored 2 publications receiving 106 citations.
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An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
Katharina Reinhard,Benjamin Rengstl,Petra Oehm,Kristina Michel,Arne Billmeier,Nina Hayduk,Oliver Klein,Kathrin Kuna,Yasmina Ouchan,Stefan Wöll,Elmar Christ,David Weber,Martin Suchan,Thomas Bukur,Matthias Birtel,Veronika Jahndel,Karolina Anna Mroz,Kathleen Hobohm,Lena M. Kranz,Mustafa Diken,Klaus Kühlcke,Özlem Türeci,Ugur Sahin +22 more
TL;DR: A two-part “CARVac” strategy to overcome poor CAR-T cell stimulation and responses in vivo is described and a nanoparticulate RNA vaccine, designed for body-wide delivery of the CAR antigen into lymphoid compartments, stimulates adoptively transferredCAR-T cells.
Journal ArticleDOI
Monitoring Translation Activity of mRNA-Loaded Nanoparticles in Mice
Sebastian Rosigkeit,Martin Meng,Christian Grunwitz,Patricia Gomes,Andreas Kreft,Nina Hayduk,Rosario Heck,Geethanjali Pickert,Kira Ziegler,Yasmin Abassi,Jasmin Röder,Leonard Kaps,Fulvia Vascotto,Tim Beissert,Sonja Witzel,Andreas Kuhn,Mustafa Diken,Detlef Schuppan,Ugur Sahin,Heinrich Haas,Ernesto Bockamp +20 more
TL;DR: The results show that this approach provides readouts that accurately report the targeting efficacy of mRNA into organs, tissue structures, and single cells as a function of the used mRNA delivery system.
Journal ArticleDOI
A TCR-like CAR Promotes Sensitive Antigen Recognition and Controlled T-cell Expansion Upon mRNA Vaccination
Matthias Birtel,Ralf-Holger Voss,Katharina Reinhard,Benjamin Rengstl,Yasmina Ouchan,Kristina Michel,Nina Hayduk,Bodo Tillmann,René Becker,Martin Suchan,Matthias Theobald,Petra Oehm,Özlem Türeci,Ugur Sahin +13 more
TL;DR: A novel heterodimeric TCR-like CAR (TCAR) designed to achieve optimal chain pairing and integration into the T cell CD3 signaling complex was developed, which mediated high antigen sensitivity and potent antigen-specific T cell effector functions in short-term in vitro assays.