T
Thomas Bukur
Researcher at University of Mainz
Publications - 24
Citations - 1381
Thomas Bukur is an academic researcher from University of Mainz. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 12, co-authored 20 publications receiving 780 citations. Previous affiliations of Thomas Bukur include University of Applied Sciences Bingen.
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Journal ArticleDOI
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma
John C. Castle,Martin Loewer,Sebastian Boegel,Jos de Graaf,Christian Bender,Arbel D. Tadmor,Valesca Boisguerin,Thomas Bukur,Patrick Sorn,Claudia Paret,Mustafa Diken,Sebastian Kreiter,Özlem Türeci,Ugur Sahin +13 more
TL;DR: An integrated map of the genome, transcriptome and immunome of an epithelial mouse tumor, the CT26 colon carcinoma cell line, which predicts that CT26 is refractory to anti-EGFR mAbs and sensitive to MEK and MET inhibitors, as have been previously reported.
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An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
Katharina Reinhard,Benjamin Rengstl,Petra Oehm,Kristina Michel,Arne Billmeier,Nina Hayduk,Oliver Klein,Kathrin Kuna,Yasmina Ouchan,Stefan Wöll,Elmar Christ,David Weber,Martin Suchan,Thomas Bukur,Matthias Birtel,Veronika Jahndel,Karolina Anna Mroz,Kathleen Hobohm,Lena M. Kranz,Mustafa Diken,Klaus Kühlcke,Özlem Türeci,Ugur Sahin +22 more
TL;DR: A two-part “CARVac” strategy to overcome poor CAR-T cell stimulation and responses in vivo is described and a nanoparticulate RNA vaccine, designed for body-wide delivery of the CAR antigen into lymphoid compartments, stimulates adoptively transferredCAR-T cells.
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HLA typing from RNA-Seq sequence reads
Sebastian Boegel,Martin Löwer,Michael K. E. Schäfer,Thomas Bukur,Jos de Graaf,Valesca Boisguerin,Özlem Türeci,Mustafa Diken,John C. Castle,Ugur Sahin +9 more
TL;DR: Because the algorithm uses standard RNA-Seq reads and requires no change to laboratory protocols, it can be used for both existing datasets and future studies, thus adding a new dimension for HLA typing and biomarker studies.
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A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.
Christina Krienke,Laura Kolb,Elif Diken,Michael Streuber,Sarah Kirchhoff,Thomas Bukur,Özlem Akilli-Öztürk,Lena M. Kranz,Hendrik Berger,Jutta Petschenka,Jutta Petschenka,Mustafa Diken,Sebastian Kreiter,Nir Yogev,Ari Waisman,Katalin Karikó,Özlem Türeci,Ugur Sahin +17 more
TL;DR: This paper showed that systemic delivery of nanoparticle-formulated 1 methylpseudouridine-modified messenger RNA (m1Ψ mRNA) coding for disease-related autoantigens results in antigen presentation on splenic CD11c+ antigen-presenting cells in the absence of costimulatory signals.
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A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines
TL;DR: The compilation of the results are a fundamental resource for all researchers selecting specific cancer cell lines based on the HLA type and HLA expression, as well as for the development of immunotherapeutic tools for novel cancer treatment modalities.