K
Krystyna Dzierzbicka
Researcher at Gdańsk University of Technology
Publications - 65
Citations - 979
Krystyna Dzierzbicka is an academic researcher from Gdańsk University of Technology. The author has contributed to research in topics: Muramyl dipeptide & Acridone. The author has an hindex of 16, co-authored 63 publications receiving 839 citations. Previous affiliations of Krystyna Dzierzbicka include University of Gdańsk.
Papers
More filters
Journal ArticleDOI
Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
TL;DR: Natural and synthetic acridine/acridone analogs, their application as anticancer drugs and methods for their preparation are reviewed.
Journal ArticleDOI
Recent developments in the synthesis and biological activity of acridine/acridone analogues
TL;DR: This survey describes acridine and acridone derivatives reported since 2013, methods of their synthesis and their potential clinical applications, as well as investigating their clinical application in Alzheimer's disease and other diseases.
Journal ArticleDOI
Synthesis and cytotoxic activity of conjugates of muramyl and normuramyl dipeptides with batracylin derivatives.
TL;DR: Preliminary screening data obtained at the National Cancer Institute have revealed that the conjugates did not expose any cytotoxic activity even at 10(-4)-10(-8) M or microg/mL.
Journal ArticleDOI
Synthesis and Antitumor Activity of Conjugates of Muramyldipeptide, Normuramyldipeptide, and Desmuramylpeptides with Acridine/Acridone Derivatives
Krystyna Dzierzbicka,Aleksander Kolodziejczyk,Barbara Wysocka-Skrzela,Andrzej Myśliwski,Danuta Sosnowska +4 more
TL;DR: The preliminary screening data indicate that the Analogues of groups A, C, and D exhibit small cytotoxic activity, whereas several analogues of type B, 4b, 4c, 4e, 4g, 4h, 4i, and 4l, exhibiting potent in vitro cytot toxic activity against a panel of human cell lines have been selected by the National Cancer Institute Evaluation Committee for further testing.
Journal ArticleDOI
Synthesis and antitumor activity of conjugates of muramyldipeptide or normuramyldipeptide with hydroxyacridine/acridone derivatives.
TL;DR: The compounds O-(1-O-benzyl-N-acetyl-muramyl-l-alanyl-d-gamma-isoglutaminyl)-9-propylamino-1-nitroacridine ester 3k exhibited high in vitro cytotoxic activity against a panel of human cell lines, prostate cancer and AIDS-related lymphoma (ARL).