K
Krzysztof Tutaj
Researcher at University of Life Sciences in Lublin
Publications - 26
Citations - 357
Krzysztof Tutaj is an academic researcher from University of Life Sciences in Lublin. The author has contributed to research in topics: Chemistry & Antioxidant. The author has an hindex of 9, co-authored 18 publications receiving 247 citations. Previous affiliations of Krzysztof Tutaj include Maria Curie-Skłodowska University & Medical University of Lublin.
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Journal ArticleDOI
Self-association of amphotericin B: spontaneous formation of molecular structures responsible for the toxic side effects of the antibiotic.
Joanna Starzyk,Marcin Gruszecki,Krzysztof Tutaj,Rafal Luchowski,Radoslaw Szlazak,Piotr Wasko,Wojciech Grudzinski,Jacek Czub,Wiesław I. Gruszecki +8 more
TL;DR: A detailed analysis of self-assembly of AmB molecules in different environments, interesting from the physiological standpoint, based on molecular spectroscopy techniques: electronic absorption, circular dichroism, steady state and time-resolved fluorescence and molecular dynamic calculations.
Journal ArticleDOI
Amphotericin B-silver hybrid nanoparticles: synthesis, properties and antifungal activity
Krzysztof Tutaj,Krzysztof Tutaj,Radoslaw Szlazak,Katarzyna Szałapata,Joanna Starzyk,Rafal Luchowski,Wojciech Grudzinski,Monika Osińska-Jaroszuk,Anna Jarosz-Wilkołazka,Agnieszka Szuster-Ciesielska,Wiesław I. Gruszecki +10 more
TL;DR: A novel hybrid system based on silver nanoparticles synthesized using a popular antifungal macrocyclic polyene amphotericin B acting both as a reducing and stabilizing/capping agent is described, which could potentially be important in future drug development and fabrication.
Journal ArticleDOI
Toward understanding of toxic side effects of a polyene antibiotic amphotericin B: fluorescence spectroscopy reveals widespread formation of the specific supramolecular structures of the drug.
Piotr Wasko,Rafal Luchowski,Krzysztof Tutaj,Wojciech Grudzinski,Przemysław Adamkiewicz,Wiesław I. Gruszecki +5 more
TL;DR: Specific aggregate formation of AmB has been concluded as a universal and ubiquitous form of molecular organization of the drug.
Journal ArticleDOI
Iodine biofortification through expression of HMT, SAMT and S3H genes in Solanum lycopersicum L.
Mariya Halka,Sylwester Smoleń,Małgorzata Czernicka,Magdalena Klimek-Chodacka,Joanna Pitala,Krzysztof Tutaj +5 more
TL;DR: It was discovered that exogenously applied 5-ISA, 3,5-diISA, 2-I beA and 4-IBeA are genuinely (endogenously) synthesised in tomato plants; to date, this has not been described for the tomato, nor for any other species of higher plant.
Journal ArticleDOI
Effect of silver nanoparticles on the immune, redox, and lipid status of chicken blood
Katarzyna Ognik,Ewelina Cholewińska,Anna Czech,Krzysztof Kozłowski,Łukasz Wlazło,Bożena Nowakowicz-Dębek,Radosław Szlązak,Krzysztof Tutaj +7 more
TL;DR: Administration of silver nanoparticles to the chickens probably led to a disturbance in protein catabolism in the organism, which is evidenced by the decrease in the activity of the liver enzymes AST and ALT and the decreased concentration of the main protein metabolism products (creatinine and urea).