http://if-pan.krakow.pl/pjp/pdf/2012/5_1020.pdf

Nanoparticles as drug delivery systems

Transport of drugs across the blood-brain barrier by nanoparticles.

Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches.

Preparation, characterization and in vitro release study of carvacrol-loaded chitosan nanoparticles.

Drug delivery to the central nervous system by polymeric nanoparticles: what do we know?

Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease.

Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles.

Chitosan nanoparticles as a new delivery system for the anti-alzheimer drug tacrine

Significant delivery of tacrine into the brain using magnetic chitosan microparticles for treating Alzheimer's disease.

Alzheimer disease is a progressive degenerative disorder of the brain characterized by a slow, progressive decline in cognitive function and behavior. As the disease advances, persons with Alzheimer disease have tough time with daily usage of things like using the phone, cooking, handling money, or driving the car. The disease is more common in elder population. It is estimated that Alzheimer disease affects 15 million people worldwide and approximately 4 million Americans. The clinical features of Alzheimer disease overlaps with common signs of aging, and other types of dementia, hence the diagnosis remains difficult. The neuropathologic hallmarks of the disorder are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration. Drugs approved for treating Alzheimer disease include acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonist. Caregivers not getting adequate information about Alzheimer disease may believe that nothing can be done to manage its symptoms. Understanding the extent of Alzheimer disease related knowledge can assist disease management that result in improved disease management and reduced care costs. This article attempts to focus on some of the important recent developments in understanding and management of Alzheimer disease.

Alzheimer disease and its management: a review.

Kumaraswamy Santhi

Papers

Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease.

Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles.

Chitosan nanoparticles as a new delivery system for the anti-alzheimer drug tacrine

Significant delivery of tacrine into the brain using magnetic chitosan microparticles for treating Alzheimer's disease.

Alzheimer disease and its management: a review.