Delhi Institute of Pharmaceutical Sciences and Research

About: Delhi Institute of Pharmaceutical Sciences and Research is a education organization based out in New Delhi, India. It is known for research contribution in the topics: Drug delivery & Medicine. The organization has 410 authors who have published 558 publications receiving 8267 citations.

Eudragit®: a technology evaluation

Abstract: Introduction: Eudragit is the brand name for a diverse range of polymethacrylate-based copolymers. It includes anionic, cationic, and neutral copolymers based on methacrylic acid and methacrylic/acrylic esters or their derivatives. Areas covered: In this review, the physicochemical characteristics and applications of different grades of Eudragit in colon-specific/enteric-coated/sustained release drug delivery and taste masking have been addressed. Expert opinion: Eudragits are amorphous polymers having glass transition temperatures between 9 to > 150oC. Eudragits are non-biodegradable, nonabsorbable, and nontoxic. Anionic Eudragit L dissolves at pH > 6 and is used for enteric coating, while Eudragit S, soluble at pH > 7 is used for colon targeting. Studies in human volunteers have confirmed that pH drops from 7.0 at terminal ileum to 6.0 at ascending colon, and Eudragit S based systems sometimes fail to release the drug. To overcome the shortcoming, combination of Eudragit S and Eudragit L which ensures d...

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications.

Abstract: The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as solution) was compared with the mixture of PVA and gelatin of the same composition. The mechanical properties of the hydrogels were characterized by tensile tests. Swelling behavior and hemocompatibility of the membrane were also evaluated. The diffusion coefficient of salicylic acid (SA), when the receptor compartment contained Ringer's solution, through the membrane was determined. SA was used as a model drug. FTIR spectra of the membranes indicated complete esterification of the free carboxylic groups of gelatin. XRD studies indicated that the crystallinity of the membranes was mainly due to gelatin. The comparison of viscosity indicated an increase in segment density within the molecular coil. The membrane had sufficient strength and water-holding capacity. Hemocompatibility suggested that the hydrogel could be tried as wound dressing and as an implantable drug delivery system. The diffusion coefficient of SA through the membrane was found to be 1.32×10−5 cm2/s. The experimental results indicated that the hydrogel could be tried for various biomedical applications.

Polymeric Hydrogels: Characterization and Biomedical Applications

Abstract: Hydrogels are cross-linked polymeric networks, which have the ability to hold water within the spaces available among the polymeric chains. The hydrogels have been used extensively in various biomedical applications, e.g., drug delivery, cell carriers and/or entrapment, wound management and tissue engineering. Though far from extensive, this article has been devoted to study the common methods used for the characterization of the hydrogels and to review the range of applications of the same in health care.

Preparation and catalytic applications of nanomaterials: a review

Abstract: Catalysts play a very important role in the chemical industries. Catalysts have been used in processes like the workup of fuels such as oil, gas and coal, purification of effluents and industrial waste gases etc. Heterogeneous catalysts are gaining much attention compared to homogeneous catalysts as they confer more selectivity and provide better yield. Research in new catalytic materials or optimization of existing catalyst systems is of enormous importance in order to increase the efficiency of the catalyst, resulting in higher product yields and purities. Currently, the research is more focused towards nanostructured catalysts with enhanced physiochemical properties. Nanoscale catalysts have high specific surface area and surface energy, which ultimately lead to the high catalytic activity. Nano-catalysts improve the selectivity of the reactions by allowing reaction at a lower temperature, reducing the occurrence of side reactions, higher recycling rates and recovery of energy consumption. Therefore, these are widely used in green chemistry, environmental remediation, efficient conversion of biomass, renewable energy development and other areas of interest. In this review the prospects, paradox and perspective of the preparation and catalytic application of nanomaterials in organic synthetic chemistry is reviewed, and an outlook of their developments is discussed.