K
Kunihiko Ikeguchi
Researcher at Jichi Medical University
Publications - 29
Citations - 1794
Kunihiko Ikeguchi is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Tyrosine hydroxylase & Adeno-associated virus. The author has an hindex of 17, co-authored 29 publications receiving 1709 citations. Previous affiliations of Kunihiko Ikeguchi include Mitsubishi Tanabe Pharma.
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Journal ArticleDOI
A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.
Shin-ichi Muramatsu,Ken-ichi Fujimoto,Seiya Kato,Hiroaki Mizukami,Sayaka Asari,Kunihiko Ikeguchi,Tadataka Kawakami,Masashi Urabe,Akihiro Kume,Toshihiko Sato,Watanabe Eiju,Keiya Ozawa,Imaharu Nakano +12 more
TL;DR: The findings provide class IV evidence regarding the safety and efficacy of AADC gene therapy and warrant further evaluation in a randomized, controlled, phase 2 setting.
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Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.
Lijun Wang,Yan-Yan Lu,Shin-ichi Muramatsu,Kunihiko Ikeguchi,Ken-ichi Fujimoto,Takashi Okada,Hiroaki Mizukami,Takashi Matsushita,Yutaka Hanazono,Akihiro Kume,Toshiharu Nagatsu,Keiya Ozawa,Imaharu Nakano +12 more
TL;DR: It is shown here that AAV-GDNF leads to substantial and long-lasting expression of transgenic GDNF in a large number of myofibers with its accumulation at the sites of neuromuscular junctions, indicating that A AV-mediated GDNF delivery to the muscle is a promising means of gene therapy for ALS.
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Triple Transduction with Adeno-Associated Virus Vectors Expressing Tyrosine Hydroxylase, Aromatic-L-Amino-Acid Decarboxylase, and GTP Cyclohydrolase I for Gene Therapy of Parkinson's Disease
Yang Shen,Shin-ichi Muramatsu,Kunihiko Ikeguchi,Ken-ichi Fujimoto,Dong-Sheng Fan,Matsuo Ogawa,Hiroaki Mizukami,Masashi Urabe,Akihiro Kume,Ikuko Nagatsu,Fumi Urano,Takahiro Suzuki,Hiroshi Ichinose,Toshiharu Nagatsu,John Monahan,Imaharu Nakano,Keiya Ozawa +16 more
TL;DR: Results suggest that GCH, in addition to TH and AADC, is important for effective gene therapy of PD, and triple transduction enhanced BH4 and dopamine production in denervated striatum of parkinsonian rats and improved the rotational behavior of the rats more efficiently than did double transduction.
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Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes
Shin-ichi Muramatsu,Ken-ichi Fujimoto,Kunihiko Ikeguchi,Nami Shizuma,Katsuyoshi Kawasaki,Fumiko Ono,Yang Shen,Lijun Wang,Hiroaki Mizukami,Akihiro Kume,Masaru Matsumura,Ikuko Nagatsu,Fumi Urano,Hiroshi Ichinose,Toshiharu Nagatsu,Keiji Terao,Imaharu Nakano,Keiya Ozawa +17 more
TL;DR: The results show that AAV vectors efficiently introduce DA-synthesizing enzyme genes into the striatum of primates with restoration of motor functions and this triple transduction method may offer a potential therapeutic strategy for PD.
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Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease
L Wang,Shin-ichi Muramatsu,Y Lu,Kunihiko Ikeguchi,K. Fujimoto,Takashi Okada,Hiroaki Mizukami,Yutaka Hanazono,Akihiro Kume,Fumi Urano,Hiroshi Ichinose,Toshiharu Nagatsu,Imaharu Nakano,Keiya Ozawa +13 more
TL;DR: Significant behavioral recovery was observed from 4–20 weeks following AAV-GDNFflag injection, indicating that a delayed delivery of GDNF gene using AAV vector is efficacious even 4 weeks after the onset of progressive degeneration in a rat model of PD.