Yutaka Hanazono

TL;DR: It is shown here that AAV-GDNF leads to substantial and long-lasting expression of transgenic GDNF in a large number of myofibers with its accumulation at the sites of neuromuscular junctions, indicating that A AV-mediated GDNF delivery to the muscle is a promising means of gene therapy for ALS.

TL;DR: It was found that the addition of FLT and especially STR during the initial brief transduction period increased engraftment with marked cells into a clinically relevant range, despite lack of evidence for expansion of engrafting cells.

TL;DR: Significant behavioral recovery was observed from 4–20 weeks following AAV-GDNFflag injection, indicating that a delayed delivery of GDNF gene using AAV vector is efficacious even 4 weeks after the onset of progressive degeneration in a rat model of PD.

TL;DR: This is the first demonstration of macroscopic fluorescent Chimeras derived from naive-like porcine PSCs, although adult chimeras remain to be produced.

TL;DR: The results suggest that the improvement in regional blood flow and cardiac function in cynomolgus monkey acute myocardial infarction is not the result of generation of transplanted cell–derived endothelial cells or cardiomyocytes; and raise the possibility that angiogenic cytokines secreted from transplanted cells potentiateAngiogenic activity of endogenous cells.