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Showing papers by "Kunisuke Izawa published in 2021"

Journal Article•DOI•
Fluorine-containing pharmaceuticals approved by the FDA in 2020: Synthesis and biological activity

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Yingjie Yu1, Aiyao Liu1, Gagan Dhawan2, Haibo Mei1, Wei Zhang3, Kunisuke Izawa, Vadim A. Soloshonok4, Vadim A. Soloshonok5, Jianlin Han1 •
Nanjing Forestry University1, University of Delhi2, University of Massachusetts Boston3, University of the Basque Country4, Ikerbasque5
27 May 2021-Chinese Chemical Letters
TL;DR: Thirteen new fluorine-containing drugs, which have been granted approval by the US Food and Drug Administration in 2020, are profiled in this review, providing a spectrum of biological activity, medicinal chemistry discovery, and synthetic approaches.

51 citations

Journal Article•DOI•
Tailor-made amino acids in the design of small-molecule blockbuster drugs.

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Jianlin Han1, Hiroyuki Konno2, Tatsunori Sato, Vadim A. Soloshonok3, Vadim A. Soloshonok4, Kunisuke Izawa •
Nanjing Forestry University1, Yamagata University2, University of the Basque Country3, Ikerbasque4
16 Apr 2021-European Journal of Medicinal Chemistry
TL;DR: In this paper, the role of amino acids (AAs) in modern health industry is well-appreciated, and they serve as key structural features in many most successful pharmaceuticals, so-called blockbuster drugs.

19 citations

Journal Article•DOI•
New pharmaceuticals approved by FDA in 2020: Small-molecule drugs derived from amino acids and related compounds.

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Aiyao Liu1, Jianlin Han1, Arina Nakano2, Hiroyuki Konno2, Hiroki Moriwaki, Hidenori Abe, Kunisuke Izawa, Vadim A. Soloshonok3, Vadim A. Soloshonok4 •
Nanjing Forestry University1, Yamagata University2, Ikerbasque3, University of the Basque Country4
29 Oct 2021-Chirality
TL;DR: Amino acids (AAs) play an important role in the modern health industry as key synthetic precursors for pharmaceuticals, biomaterials, biosensors, and drug delivery systems.

14 citations

Journal Article•DOI•
Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent

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Yupiao Zou1, Ryosuke Takeda, Jianlin Han1, Hiroyuki Konno2, Hiroki Moriwaki, Hidenori Abe, Kunisuke Izawa, Vadim A. Soloshonok3, Vadim A. Soloshonok4 •
Nanjing Forestry University1, Yamagata University2, Ikerbasque3, University of the Basque Country4
07 Jun 2021-European Journal of Organic Chemistry

4 citations

Journal Article•DOI•
Electrochemical Approaches for Preparation of Tailor-Made Amino Acids

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Nana Wang, Jingcheng Xu, Haibo Mei, Hiroki Moriwaki, Kunisuke Izawa, Vadim A. Soloshonok, Jianlin Han 
01 Jan 2021-Chinese Journal of Organic Chemistry

3 citations

Journal Article•DOI•
Comparative study of different chiral ligands for dynamic kinetic resolution of amino acids.

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Keita Nagaoka1, Arina Nakano1, Jianlin Han2, Tsubasa Sakamoto, Hiroyuki Konno1, Hiroki Moriwaki, Hidenori Abe, Kunisuke Izawa, Vadim A. Soloshonok3 •
Yamagata University1, Nanjing Forestry University2, University of the Basque Country3
17 Aug 2021-Chirality
TL;DR: In this article, a comparative case study of synthetic performance of four different ligands in DKR of six AAs representing aryl-, benzyl-, alkyl-, and long-alkyl-type derivatives is presented.

1 citations