H
Hiroyuki Konno
Researcher at Yamagata University
Publications - 137
Citations - 1572
Hiroyuki Konno is an academic researcher from Yamagata University. The author has contributed to research in topics: Amino acid & Enantioselective synthesis. The author has an hindex of 19, co-authored 137 publications receiving 1186 citations. Previous affiliations of Hiroyuki Konno include Kyoto University & Shinshu University.
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Journal ArticleDOI
Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
Kenichi Akaji,Hiroyuki Konno,Hironori Mitsui,Kenta Teruya,Yasuhiro Shimamoto,Yasunao Hattori,Takeshi Ozaki,Masami Kusunoki,Akira Sanjoh +8 more
TL;DR: The design and evaluation of low molecular weight peptide-based severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL) protease inhibitors are described, and X-ray crystallography provided insights into the protein-ligand interactions.
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Metal-Assisted Stabilization and Probing of Collagenous Triple Helices
TL;DR: This metal-coordinating system possesses potential to be used to stabilize the triple-helical conformation as well as to probe the folding status of collagen model peptides.
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Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae
Kazuto Nosaka,Mari Onozuka,Hiroyuki Konno,Yuko Kawasaki,Hiroshi Nishimura,Mamoru Sano,Kenichi Akaji +6 more
TL;DR: The possibility that the induction of THI genes is triggered by the activation of the complex attributed to decrease in intracellular TDP and the elevated complex in the autoregulatory fashion further upregulates THi genes is discussed.
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Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor
TL;DR: Compound 7, the ideal amyloid β aggregation inhibitor in vitro among synthesized curcumin analogues, has not only potent anti amyloids β aggregation effects, but also water solubility more than 160 times that ofCurcumin.
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Total synthesis of miraziridine A and identification of its major reaction site for cathepsin B
Hiroyuki Konno,Kanako Kubo,Hidefumi Makabe,Emi Toshiro,Naoyuki Hinoda,Kazuto Nosaka,Kenichi Akaji +6 more
TL;DR: In this paper, the synthesis of miraziridine A, a pentapeptide derivative isolated from marine sponge, and its truncated analogs has been achieved, and a side-chain unprotected vinylogous arginine was condensed with an aziridine-containing fragment prepared by a conventional solid-phase procedure.