K
Kunisuke Izawa
Researcher at Ajinomoto
Publications - 139
Citations - 3842
Kunisuke Izawa is an academic researcher from Ajinomoto. The author has contributed to research in topics: Amino acid & Yield (chemistry). The author has an hindex of 21, co-authored 139 publications receiving 2984 citations. Previous affiliations of Kunisuke Izawa include Rega Institute for Medical Research.
Papers
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Journal ArticleDOI
Production of (R)-3-amino-3-phenylpropionic acid and (S)-3-amino-3-phenylpropionic acid from (R,S)-N-acetyl-3-amino-3-phenylpropionic acid using microorganisms having enantiomer-specific amidohydrolyzing activity.
Hisashi Kawasaki,Koutaro Koyama,Sachio Kurokawa,Kunihiko Watanabe,Masakazu Nakazawa,Kunisuke Izawa,Tsuyoshi Nakamatsu +6 more
TL;DR: Screening for microorganisms capable of amidohydrolyzing (R,S)-N-acetyl-3-amino- 3-phenylpropionic acid in an enantiomer-specific manner was performed, and enantiomersically pure (R)-β-Phe and (S)-β -Phe with a high molar conversion yield were obtained from the racemic substrate.
Book ChapterDOI
Synthesis and Biological Activity of Fluorinated Nucleosides
Patent
Production method of famciclovir and production and crystallization method of intermediate therefor
TL;DR: In this paper, an N-9 position alkylated form of 2-amino-6-halopurine was selectively precipitated by subjecting a mixture of a mixture containing the n-9position alkylation form and an n-7position alization form to a crystallization step using a mixed solvent of an organic solvent and water.
Journal ArticleDOI
Asymmetric synthesis of (S)-α-(octyl)glycine via alkylation of Ni(II) complex of chiral glycine Schiff base.
Bo Fu,Ryosuke Takeda,Yupiao Zou,Hiroyuki Konno,Hiroki Moriwaki,Hidenori Abe,Jianlin Han,Kunisuke Izawa,Vadim A. Soloshonok +8 more
TL;DR: Under the optimized conditions, the alkylation proceeds with excellent yield and diastereoselectivity and the observed stereochemical outcome and convenient reaction conditions bode well for application of this method for large-scale asymmetric synthesis of (S)-2-aminodecanoic acid and its derivatives.
Journal ArticleDOI
Synthesis of (6S,8R)-6-(1'-hydroxyethyl) carbapenem, a thienamycin type
Shigeo Nozoe,Tomohisa Ohta,Sojiro Shiokawa,Eiichiro Iwashita,Nobuaki Sato,Sakurai Kuniya,Takashi Ineyama,Hiroyuki Izawa,Kunisuke Izawa +8 more
TL;DR: In this paper, title carbapenem (1) having thienamycin type of side chain at C-6 was synthesized from L-glutamic acid.