Kunisuke Izawa

TL;DR: Three new approaches to the assembly of Amprenavir are discussed, and a synthetic route in which an (S)-tetrahydrofuranyloxy carbonyl is attached to l-phenylalanine appears to be the most promising manufacturing process, in that it offers satisfactory stereoselectivity in fewer steps.

TL;DR: In this paper, Hypophosphorous acid and dialkyl phosphites are used to reduce O-thiocarbonyl groups or halides at the sugar part of nucleoside derivatives and give the corresponding hydrocarbons in high yield.

TL;DR: A review of the recent progress in identification of purely chemical, small-molecule drugs of considerable potential to be used as effective therapeutics for prevention, diagnosis, and treatment of EBOV profiles three compounds – favipiravir, BCX-4430, and brincidofovir – identified by the World Health Organization as high-priority targets.

TL;DR: This review article summarizes examples of asymmetric synthesis of tailor-made α-amino acids via the corresponding Ni(II) complexes, reported in the literature over the last four years, with the emphasis given to practicality, scalability, cost-structure and recyclability of the chiral tridentate ligands.

TL;DR: Excellent yields and diastereoselectivity coupled with reliable and easy scalability render this method of immediate use for practical synthesis of (1R,2S)-vinyl-ACCA.