K
Kunsala T. D. S. Yapa
Researcher at University of Queensland
Publications - 7
Citations - 489
Kunsala T. D. S. Yapa is an academic researcher from University of Queensland. The author has contributed to research in topics: Breast cancer & Signal transduction. The author has an hindex of 6, co-authored 7 publications receiving 386 citations.
Papers
More filters
Journal ArticleDOI
Altered calcium signaling in cancer cells.
TL;DR: Findings from some of the studies that have assessed the remodeling of the calcium signal associated with tumorigenesis and/or processes important in invasion and metastasis are presented and the potential of new methodologies is discussed.
Journal ArticleDOI
TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells
Iman Azimi,Iman Azimi,Michael J. G. Milevskiy,Elke Kaemmerer,Elke Kaemmerer,Dane Turner,Kunsala T. D. S. Yapa,Melissa A. Brown,Erik W. Thompson,Erik W. Thompson,Erik W. Thompson,Sarah J. Roberts-Thomson,Gregory R. Monteith,Gregory R. Monteith +13 more
TL;DR: The defined roles of TRPC1 identified here could be therapeutically exploited for the control of oncogenic pathways in breast cancer cells.
Journal ArticleDOI
Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells
Amelia A. Peters,S. Y. N. Jamaludin,Kunsala T. D. S. Yapa,Silke B. Chalmers,Adrian P. Wiegmans,H. Lim,Michael J. G. Milevskiy,Iman Azimi,Felicity M. Davis,Korinne Northwood,Elena Pera,Daneth L. Marcial,Eloise Dray,Nigel J. Waterhouse,Peter J. Cabot,Thomas J. Gonda,Paraic A. Kenny,Melissa A. Brown,Kum Kum Khanna,Sarah J. Roberts-Thomson,Gregory R. Monteith +20 more
TL;DR: In this article, the authors defined the overexpression of transient receptor potential vanilloid 4 (TRPV4) in a subgroup of breast cancers of the basal molecular subtype.
Journal ArticleDOI
ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses
Iman Azimi,Iman Azimi,Michael J. G. Milevskiy,Silke B. Chalmers,Kunsala T. D. S. Yapa,Mélanie Robitaille,Christopher Henry,Gregory J. Baillie,Erik W. Thompson,Erik W. Thompson,Sarah J. Roberts-Thomson,Gregory R. Monteith +11 more
TL;DR: This study defines ORAI3 as a potential fine-tuner for processes relevant to the progression of basal breast cancers, and finds that ORAi3 is over-expressed in the mesenchymal subtype of triple-negative breast cancer.
Journal ArticleDOI
The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer
Elena Pera,Elke Kaemmerer,Elke Kaemmerer,Michael J. G. Milevskiy,Kunsala T. D. S. Yapa,Jake S. O’Donnell,Jake S. O’Donnell,Melissa A. Brown,Fiona Simpson,Fiona Simpson,Amelia A. Peters,Sarah J. Roberts-Thomson,Gregory R. Monteith,Gregory R. Monteith +13 more
TL;DR: Elevated levels of Cav3.2 may be a potential differential biomarker for survival and treatment response in specific breast cancer subtypes and add to the complex and diverse role of Ca2+-signalling in breast cancer progression and treatment.