K
Kurt Blaser
Researcher at Swiss Institute of Allergy and Asthma Research
Publications - 263
Citations - 27218
Kurt Blaser is an academic researcher from Swiss Institute of Allergy and Asthma Research. The author has contributed to research in topics: T cell & Immunoglobulin E. The author has an hindex of 85, co-authored 263 publications receiving 26461 citations. Previous affiliations of Kurt Blaser include University of Toronto & University of Zurich.
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Journal ArticleDOI
Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells
Miibeccel Akdis,Johan Verhagen,Alison Taylor,Fariba Karamloo,Christian Karagiannidis,Reto Crameri,Sarah Thunberg,Günnur Deniz,Günnur Deniz,Rudolf Valenta,Helmut Fiebig,Christian Kegel,Rainer Disch,Carsten B. Schmidt-Weber,Kurt Blaser,Cezmi A. Akdis +15 more
TL;DR: This paper showed that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy, indicating that a change in the dominant subset may lead to allergy development or recovery.
Journal ArticleDOI
Role of interleukin 10 in specific immunotherapy.
TL;DR: It is demonstrated that the anergic state results from increased IL-10 production by SIT, which causes specific anergy in peripheral T cells, and regulates specific IgE and IgG4 production toward normal IgE-related immunity.
Journal ArticleDOI
IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy.
Marek Jutel,Mübeccel Akdis,Ferah Budak,Carmen Aebischer-Casaulta,Maria Wrzyszcz,Kurt Blaser,Cezmi A. Akdis +6 more
TL;DR: A deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens is demonstrated.
Journal ArticleDOI
Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage.
TL;DR: Evidence of distinct T-cell activation resulting in different spectra of cytokines in allergic and nonallergic asthma is provided, suggesting that IL-5 is responsible for the characteristic eosinophilia of asthma.
Journal ArticleDOI
Mechanisms of immune suppression by interleukin‐10 and transforming growth factor‐β: the role of T regulatory cells
TL;DR: Induction of antigen‐specific Tr1 cells can re‐direct an inappropriate immune response against allergens or auto‐antigens using a broad range of suppressor mechanisms.