K
Kusum K. Kharbanda
Researcher at Veterans Health Administration
Publications - 123
Citations - 3360
Kusum K. Kharbanda is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Liver injury & Alcoholic liver disease. The author has an hindex of 29, co-authored 108 publications receiving 2603 citations. Previous affiliations of Kusum K. Kharbanda include University of Nebraska Medical Center & Nebraska Medical Center.
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Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis
TL;DR: The newer publicized advances of research in murine colitis models that focus upon the disruption of the barrier function of the intestine, effects of mucin on the development of colitis, alterations found in microbial balance and resultant changes in the metabolome specifically in the DSS colitis murine model and its relation to the pathogenesis of IBD are reviewed.
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Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium
Vishnudutt Purohit,Manal F. Abdelmalek,Shirish Barve,Norlin J. Benevenga,Charles H. Halsted,Neil Kaplowitz,Kusum K. Kharbanda,Qi Ying Liu,Shelly C. Lu,Craig J. McClain,Christine A. Swanson,Samir Zakhari +11 more
TL;DR: This report is a summary of a symposium on the role of S-adenosylmethionine, betaine, and folate in the treatment of alcoholic liver disease, which was organized by the National Institute on Alcohol Abuse and Alcoholism in collaboration with the Office of Dietary Supplements and the National Center for Complementary and Alternative Medicine.
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Treatment options for alcoholic and non-alcoholic fatty liver disease: A review.
TL;DR: The involvement of several inter-related pathways in the pathogenesis of these diseases suggests that a single therapeutic agent is unlikely to be an effective treatment strategy, and a combination therapy towards multiple targets would eventually be required.
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S‐Adenosyl‐L‐Methionine Co‐administration Prevents the Ethanol‐Elicited Dissociation of Hepatic Mitochondrial Ribosomes in Male Rats
TL;DR: It is suggested that mitoribosome dissociation precedes respiratory complex depressions in alcoholic animals and that dietary supplementation of SAM prevents some of the early mitochondrial lesions associated with chronic ethanol consumption.
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S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver.
Shannon M. Bailey,Gloria Robinson,Anita Pinner,Laura Chamlee,Elena Ulasova,Melissa Pompilius,Grier P. Page,David C. Chhieng,Nirag Jhala,Aimee Landar,Kusum K. Kharbanda,Scott W. Ballinger,Victor M. Darley-Usmar +12 more
TL;DR: New molecular targets through which S-adenosylmethionine may work to alleviate one critical component of alcohol-induced liver injury: mitochondria dysfunction are revealed.