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Craig J. McClain
Researcher at University of Louisville
Publications - 547
Citations - 29097
Craig J. McClain is an academic researcher from University of Louisville. The author has contributed to research in topics: Alcoholic liver disease & Liver injury. The author has an hindex of 88, co-authored 495 publications receiving 25426 citations. Previous affiliations of Craig J. McClain include Jewish Hospital & Tufts University.
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Journal ArticleDOI
Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients
Alexander Khoruts,Laura L. Stahnke,Craig J. McClain,George Logan,John I. Allen,John I. Allen +5 more
TL;DR: The data suggest that tumor necrosis factor‐α and interleukin‐1α are related to some of the metabolic consequences of both acute and chronic alcohol‐induced liver disease, whereas interleukain‐6 is related to abnormalities seen in acute liver injury.
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Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin.
Ina Bergheim,S. Weber,Miriam B. Vos,Sigrid Krämer,Valentina Volynets,Seline Kaserouni,Craig J. McClain,Stephan C. Bischoff +7 more
TL;DR: The hypothesis that high fructose consumption may not only lead to liver damage through overfeeding but also may be directly pro-inflammatory by increasing intestinal translocation of endotoxin is supported.
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Cytokines in alcoholic liver disease.
TL;DR: There is an emerging rationale for use of anticytokine therapy in alcoholic liver disease, with the goal of maintaining beneficial effects of cytokines and inhibition of the deleterious effects of these potentially toxic agents.
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Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota
Yun Teng,Yi Ren,Mohammed Sayed,Xin Hu,Chao Lei,Anup Kumar,Elizabeth Hutchins,Jingyao Mu,Zhongbin Deng,Chao Luo,Kumaran Sundaram,Mukesh K. Sriwastva,Lifeng Zhang,Michael Hsieh,Rebecca Reiman,Bodduluri Haribabu,Jun Yan,Venkatakrishna R. Jala,Donald M. Miller,Kendall Van Keuren-Jensen,Michael L. Merchant,Craig J. McClain,Craig J. McClain,Juw Won Park,Nejat K. Egilmez,Huang-Ge Zhang,Huang-Ge Zhang +26 more
TL;DR: It is demonstrated that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology and reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.
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Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment.
Lara M. Bull-Otterson,Wenke Feng,Irina A. Kirpich,Yuhua Wang,Xiang Qin,Yanlong Liu,Leila Gobejishvili,Swati Joshi-Barve,Tulin Ayvaz,Joseph F. Petrosino,Maiying Kong,David F. Barker,Craig J. McClain,Shirish Barve +13 more
TL;DR: Overall, significant alterations in the gut microbiome over time occur in response to chronic alcohol exposure and correspond to increases in intestinal barrier dysfunction and development of ALD.