Kwang Kyun Park

TL;DR: Several chemopreventive phytochemicals have been shown to inhibit COX-2 and iNOS expression by blocking improper NF-kappa B activation, and multiple lines of compelling evidence indicate that extracellular-regulatedprotein kinase and p38 mitogen-activated protein kinase are key elements of the intracellular signaling cascades responsible for NF-Kappa Bactivation in response to a wide array of external stimuli.

TL;DR: The methanol extract of heat-processed neoginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ions plus ascorbic acid and inhibited TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment.

TL;DR: Topical application of [6]-gingerol onto shaven backs of female ICR mice prior to each topical dose of 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis and suppressed TPA-induced epidermal ornithine decarboxylase activity and inflammation.

TL;DR: It is likely that the anti-tumor promoting activity of Rg(3), a major ginsenoside derived from heat-processed ginseng is mediated possibly through down-regulation of NF-kappaB and AP-1 transcription factors.

TL;DR: The results of this study suggest that capsaicin and diallyl sulfide suppress VC- and NDMA-induced mutagenesis or tumorigenesis in part through inhibition of the cytochrome P-450 IIE1 isoform responsible for activation of these carcinogens.