Showing papers in "Cancer Letters in 1998"

TL;DR: EGCG at a concentration range of 40-200 microM induced a significant amount of apoptosis in WI38VA cultures, but not inWI38 cultures, as determined by terminal deoxynucleotidyl transferase assay.

TL;DR: The role of hyaluronate and its receptor CD44 in cell-cell and cell-matrix adhesion and cell activation as well as on the putative role in tumor metastasis and morphogenesis is focused on.

TL;DR: First evidence is reported that EGCG is the active component in green tea and induces apoptosis in human prostate cancer cells, which is found to occur via apoptotic cell death.

TL;DR: Topical application of [6]-gingerol onto shaven backs of female ICR mice prior to each topical dose of 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis and suppressed TPA-induced epidermal ornithine decarboxylase activity and inflammation.

TL;DR: The shortcomings of MCS as a tumor model include limited knowledge of the mechanisms leading to necrosis/apoptosis of core cells, the production of an extracellular matrix (ECM) by tumor cells instead of intratumoral normal cell populations and the complex relationship of M CS parameters like size, growth regulation, synthesis of ECM components and others on the origin and pretreatment of the tumor cells and specific culture conditions.

TL;DR: The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death, suggesting that [6]-gingerol and [ 6]-paradol possess potential cytot toxic/cytostatic activities.

TL;DR: Normal diploid fibroblasts were less sensitive than the cancer cell lines to the growth inhibitory effects of selenomethionine, demonstrating the differential sensitivity of tumor cells and normal cells to selenometrichionines.

TL;DR: Curcumin exerts a cytostatic effect at G2/M which explains its antiproliferative activity, and the presence of the diketone moiety in the curcumin molecule seems to be essential for the inhibitory activity.

TL;DR: Results suggest that two hydroxyls (in positions 7 and 8) or 7-methoxy substituents are essential for the antiestrogenic activity of flavonoids.

TL;DR: Results indicate that PCA possesses potential as a cancer chemopreventive agent against tumor promotion and suppression on the TPA-induced hyperplasia in the skin and edema of mouse ears.

TL;DR: It is suggested that supplementation with antioxidants might protect smokers from oxidative damages and could reduce cancer risk or other diseases caused by free radicals associated with smoking.

TL;DR: It is shown by in vitro cytotoxicity assay and in vivo inhibition of tumor growth in hamsters that the triptolide was also highly effective against cholangiocarcinoma, a highly fatal tumor predominantly occurring in developing countries.

TL;DR: In the presence of Cu(II), curcumin caused breakage of calf thymus and supercoiled plasmid pBR322 DNA and the results are discussed in relation to the established pro-oxidant activities of other known anti-oxIDants.

TL;DR: The present data suggest that the naphthoquinones, juglone and plumbagin, could be promising chemopreventive agents for human intestinal neoplasia.

TL;DR: The data suggest that resveratrol inhibits tumorigenesis in mouse skin through interference with pathways of reactive oxidants and possibly by modulating the expression of c-fos and TGF-beta1.

TL;DR: It is found that 7-hydroxyflavone and apigenin are the most effective aromatase and 17beta-Hydroxysteroid dehydrogenase inhibitors, respectively.

TL;DR: The effects of LA and CLA on AA composition of phospholipids and subsequent arachidonate-derived PGE2 synthesis will provide insight into the anti-promoter mechanisms of CLA.

TL;DR: This randomized study failed to show synergy to chemotherapy and radiation therapy in high-grade astrocytomas concerning survival and needs more information concerning the optimal route of application, the optimal dosage and the spectrum of tumor entities where it is synergistic with cytostatic chemotherapy and perhaps even radiation therapy.

TL;DR: It is demonstrated that guduchi killed the cells very effectively in vitro and deserves attention as an antineoplastic agent.

TL;DR: To identify the intercellular signal-transducing proteins and receptors produced by cancer cells, it is attempted to clone cDNAs encoding secreted and type I membrane proteins using a signal sequence trap (SST) method with some modifications.

TL;DR: Genistein significantly inhibited cell growth of MCF-7, MDAMB-231 and HBL-100 cell lines, but not of skin-derived fibroblasts and counteracted the growth-stimulatory effects exerted by estradiol and growth factors.

TL;DR: The results suggest that some of the cytokine effects on the ubiquitin system gene expression could be related to the enhanced skeletal muscle proteolysis found during cancer cachexia and other pathological states.

TL;DR: Kerbel et al. as discussed by the authors showed that hyaluronidase has the potential to reverse both intrinsic and acquired drug resistance in solid tumors, such as EMT-6, which are sensitive to its antiadhesive effects.

TL;DR: Results suggest that TTF-1 can be favourably added to the immunohistochemical diagnostic panel for distinction between AC of the lung involving the pleura and pleural MM.

TL;DR: It is considered that passive targeting to the tumor by liposomalization elevated the SN-38 level in the tumor especially and increased the antitumor activity of CPT-11.

TL;DR: It is indicated that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production.

TL;DR: The M1 member of the mu class of the glutathione S-transferase (GSTM1) gene is present in about 50% of individuals, and those of the GSTT1-positive genotype had a two-fold risk of urothelial cancer, although not significantly; a significant interaction between the GSTM1 genotype and smoking status was found.

TL;DR: It is suggested that TNF may, in part, be responsible for the loss of protein in skeletal muscle of tumour-bearing mice.

TL;DR: It appears that the innate Bel7402 cells might be useful in screening new antitumour drugs or new chemosensitisers which could overcome the innate or acquired resistant mechanism, and the toxicity and reversal effects with 5-FU are different from those known to be P-gp substrates such as VCR, Dox, and taxol.

TL;DR: It is suggested that a wide variety of edible plants in Japan contain the secondary metabolites carrying cancer preventive activity through reduction of excess amounts of NO.