K
Kwang Seok Ahn
Researcher at University of Texas MD Anderson Cancer Center
Publications - 38
Citations - 5859
Kwang Seok Ahn is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Kinase & IκBα. The author has an hindex of 31, co-authored 38 publications receiving 5369 citations.
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Journal ArticleDOI
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism
Santosh K. Sandur,Manoj K. Pandey,Bokyung Sung,Kwang Seok Ahn,Akira Murakami,Gautam Sethi,Pornngarm Limtrakul,Vladimir Badmaev,Bharat B. Aggarwal +8 more
TL;DR: It is demonstrated that different analogs of curcumin present in turmeric exhibit variable anti-inflammatory and anti-proliferative activities, which do not correlate with their ability to modulate the ROS status.
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Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer
Bharat B. Aggarwal,Gautam Sethi,Kwang Seok Ahn,Santosh K. Sandur,Manoj K. Pandey,Ajaikumar B. Kunnumakkara,Bokyung Sung,Haruyo Ichikawa +7 more
TL;DR: Signal‐transducer‐and‐activator‐of‐transcription‐3 (STAT3), a member of a family of six different transcription factors, is closely linked with tumorigenesis.
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Transcription Factor NF-κB: A Sensor for Smoke and Stress Signals
TL;DR: The constitutive activation of NF‐κB has been linked with a wide variety of human diseases, including asthma, atherosclerosis, AIDS, rheumatoid arthritis, diabetes, osteoporosis, Alzheimer's disease, and cancer.
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Natural products as a gold mine for arthritis treatment
Dinesh Khanna,Gautam Sethi,Kwang Seok Ahn,Manoj K. Pandey,Ajaikumar B. Kunnumakkara,Bokyung Sung,Amita Aggarwal,Bharat B. Aggarwal +7 more
TL;DR: Several preclinical and clinical studies suggest that these agents have potential for arthritis treatment, and the large number of inexpensive natural products that can modulate inflammatory responses, but lack side effects, constitute 'goldmines' for the treatment of arthritis.
Journal ArticleDOI
Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-κB Activation and NF-κB-regulated Gene Products Through Modulation of p65 and IκBα Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents
TL;DR: It is found that plumbagin inhibited NF-κB activation induced by TNF, and other carcinogens and inflammatory stimuli (e.g. phorbol 12-myristate 13-acetate, H2O2, cigarette smoke condensate, interleukin-1β, lipopolysaccharide, and okadaic acid).