K
Kwang Youl Lee
Researcher at Chonnam National University
Publications - 17
Citations - 1548
Kwang Youl Lee is an academic researcher from Chonnam National University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 10 publications receiving 1299 citations.
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Journal ArticleDOI
High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice.
Jin Hee Kim,Sang Rok Lee,Li Hua Li,Li Hua Li,Hye Jeong Park,Hye Jeong Park,Jeong Hoh Park,Kwang Youl Lee,Myeong Kyu Kim,Boo Ahn Shin,Seok-Yong Choi +10 more
TL;DR: Western blotting and confocal microscopic analyses revealed that among the four 2As, the one derived from porcine teschovirus-1 (P2A) has the highest cleavage efficiency in all the contexts examined.
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RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation.
Jung Ha Kim,Kabsun Kim,Bang Ung Youn,Hye Mi Jin,Ji-Young Kim,Jang Bae Moon,Aeran Ko,Sang-Beom Seo,Kwang Youl Lee,Nacksung Kim +9 more
TL;DR: It is demonstrated that RANKL induces HAT-mediated NFATc1 acetylation and stability, and subsequently increases the transcriptional activity of NFAT c1 during osteoclast differentiation.
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Akt phosphorylates and regulates the osteogenic activity of Osterix
TL;DR: The results suggest that Akt activity enhances the osteogenic function of Osterix, at least in part, through protein stabilization and that BMP-2 regulates the osteogenically-modulated function of SOTA, at at least at part,Through Akt.
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Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation.
TL;DR: Findings suggest that XN stimulates osteoblast differentiation by activation of RUNX2 via mechanisms related to the p38 MAPK and ERK signaling pathway, which may be an important therapeutic target for osteoporosis.
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Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors.
Suhui Yang,Daulat Bikram Khadka,Suk Hee Cho,Hye-Kyung Ju,Kwang Youl Lee,Ho Jae Han,Kyung-Tae Lee,Won-Jea Cho +7 more
TL;DR: The successful application of virtual screening for hit compound identification with chemical libraries using SurflexDock is shown and it is proposed that the novel compound 5p can be an effective JAK2 inhibitor candidate for further antitumor agent research.