K
Kylie M Drake
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 2
Citations - 391
Kylie M Drake is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Mesenchymal stem cell & Endothelium. The author has an hindex of 2, co-authored 2 publications receiving 310 citations.
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Journal ArticleDOI
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
Lu Long,Mark L. Ormiston,Xudong Yang,Mark Southwood,Stefan Gräf,Rajiv D. Machado,Matthias Mueller,Bernd Kinzel,Lai Ming Yung,Janine Mary Wilkinson,Stephen D Moore,Kylie M Drake,Micheala A. Aldred,Paul B. Yu,Paul D. Upton,Nicholas W. Morrell +15 more
TL;DR: Administration of BMP9 reversed established PAH in mice bearing a heterozygous knock-in allele of a human BMPR2 mutation, R899X, and demonstrated the promise of direct enhancement of endothelial BMP signaling as a new therapeutic strategy for PAH.
Journal ArticleDOI
Feasibility of mesenchymal stem cell culture expansion for a phase I clinical trial in multiple sclerosis
Sarah M. Planchon,Karen Lingas,Jane Reese Koç,Brittney M Hooper,Basabi Maitra,R. M. Fox,Peter B. Imrey,Kylie M Drake,Micheala A. Aldred,Hillard M. Lazarus,Jeffrey A. Cohen +10 more
TL;DR: Culture expansion of mesenchymal stem cells from multiple sclerosis patients as donors is feasible, however, culture time should be minimized for cell products designated for therapeutic administration.