Stephen D Moore

TL;DR: Administration of BMP9 reversed established PAH in mice bearing a heterozygous knock-in allele of a human BMPR2 mutation, R899X, and demonstrated the promise of direct enhancement of endothelial BMP signaling as a new therapeutic strategy for PAH.

TL;DR: In the INTRINSIC RV trial, among those randomized, DDDR AVSH was associated with similar outcomes as with VVI backup pacing, and was not inferior to VVI programming.

TL;DR: In both mouse models, the development of PAH was linked to elevated interleukin-23 production, whereas systemic hypotension in Ncr1-Gfp mice was accompanied by a loss of angiopoietin-2, and these results support an important role for NK cells in the regulation of pulmonary and systemic vascular function and the pathogenesis ofPAH.

TL;DR: The need for revising the initial ICD shock configuration to achieve a 10 J safety margin appears extremely low and of low risk.

TL;DR: An increase in CD45.1/CD45.2 reconstitution in the bone marrow that persists in the spleen, thymus and blood is reported and a sex-specific difference in reconstitutes efficiencies is identified, with female mice exhibiting a greater bias towards CD 45.2 Reconstitution than males.