Kylie Thaler

TL;DR: Current evidence does not warrant recommending a particular second-generation antidepressant on the basis of differences in efficacy, but differences in onset of action and adverse events may be considered when choosing a medication.

TL;DR: It is suggested that trained individuals using the GRADE approach improves reliability in comparison to intuitive judgments about the QoE and that two individual raters can reliably assess theQoE using the Grading of Recommendations, Assessment, Development, and Evaluation system.

TL;DR: Having low socioeconomic status (SES) and/or living in low and middle income countries (LMIC) increased the risk of developing cardiovascular diseases (CVD), lung and gastric cancer, type 2 diabetes, and chronic obstructive pulmonary disease (COPD) and low SES increased therisk of mortality from lung cancer, COPD, and reduced breast cancer survival in HIC.

TL;DR: This work discusses the issues faced by three major actors of the healthcare system: patients, healthcare practitioners, and systematic reviewers through the concept of "filter failure", positing that the main problem is not that there is "too much information", but that the traditional means of managing and evaluating information are ill-suited to the realities of the digital age.

TL;DR: A systematic review of double-blind, randomised controlled trials of antidepressants for treatment of abdominal pain-related FGIDs in children and adolescents found no statistically significant differences between amitriptyline and placebo and no clear conclusions on the risks of harms can be drawn.