Vijay K Shukla

TL;DR: Credibility is increased if subgroup effects are based on a small number of a priori hypotheses with a specified direction; subgroup comparisons come from within rather than between studies; tests of interaction generate low P-values; and have a biological rationale.

TL;DR: Decisions regarding indirectness of patients and interventions depend on an understanding of whether biological or social factors are sufficiently different that one might expect substantial differences in the magnitude of effect.

TL;DR: This article addresses GRADE's approach to determining the direction and strength of a recommendation, which describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and desirable outcomes ofinterest, confidence in the estimates ofEffect, estimates of values and preferences, and resource use.

TL;DR: Further validation of AMSTAR is needed to assess its validity, reliability and perceived utility by appraisers and end users of reviews across a broader range of systematic reviews.

TL;DR: It is suggested that trained individuals using the GRADE approach improves reliability in comparison to intuitive judgments about the QoE and that two individual raters can reliably assess theQoE using the Grading of Recommendations, Assessment, Development, and Evaluation system.