L
L. F. Dell'Osso
Researcher at Case Western Reserve University
Publications - 3
Citations - 2307
L. F. Dell'Osso is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: RPE65 & Smooth pursuit. The author has an hindex of 2, co-authored 3 publications receiving 2172 citations. Previous affiliations of L. F. Dell'Osso include Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Albert M. Maguire,Francesca Simonelli,Eric A. Pierce,Edward N. Pugh,Federico Mingozzi,Jeannette L. Bennicelli,Sandro Banfi,Kathleen A. Marshall,Francesco Testa,Enrico Maria Surace,Settimio Rossi,Arkady Lyubarsky,Valder R. Arruda,Barbara A. Konkle,Edwin M. Stone,Edwin M. Stone,Junwei Sun,Jonathan B. Jacobs,L. F. Dell'Osso,Richard W. Hertle,Jian Xing Ma,T. Michael Redmond,Xiaosong Zhu,Bernd Hauck,Olga Zelenaia,Kenneth S. Shindler,Maureen G. Maguire,J. Fraser Wright,Nicholas J. Volpe,Jennifer Wellman McDonnell,Alberto Auricchio,Katherine A. High,Katherine A. High,Jean Bennett +33 more
TL;DR: This study investigated the safety of subretinal delivery of a recombinant adeno-associated virus (AAV) carrying RPE65 complementary DNA (cDNA) and found three patients with LCA2 had an acceptable local and systemic adverse-event profile after delivery of AAV2.hRPE65v2.
Journal ArticleDOI
Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer
Jeannette L. Bennicelli,J F Wright,J F Wright,András M. Komáromy,Jonathan B. Jacobs,Bernd Hauck,Olga Zelenaia,Federico Mingozzi,Daniel Hui,Daniel C. Chung,Tonia S. Rex,Zhangyong Wei,Guang Qu,Shangzhen Zhou,Caroline J. Zeiss,Valder R. Arruda,Gregory M. Acland,L. F. Dell'Osso,Katherine A. High,Albert M. Maguire,Jean Bennett +20 more
TL;DR: The data demonstrate that AAV2.RPE65 delivers the RPE65 transgene efficiently and quickly to the appropriate target cells in vivo in animal models, and holds great promise for treatment of LCA due to R PE65 mutations.