N
Nicholas J. Volpe
Researcher at Northwestern University
Publications - 175
Citations - 7874
Nicholas J. Volpe is an academic researcher from Northwestern University. The author has contributed to research in topics: Optic nerve & Visual acuity. The author has an hindex of 35, co-authored 171 publications receiving 7103 citations. Previous affiliations of Nicholas J. Volpe include University of Pennsylvania & Yeshiva University.
Papers
More filters
Journal ArticleDOI
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Albert M. Maguire,Francesca Simonelli,Eric A. Pierce,Edward N. Pugh,Federico Mingozzi,Jeannette L. Bennicelli,Sandro Banfi,Kathleen A. Marshall,Francesco Testa,Enrico Maria Surace,Settimio Rossi,Arkady Lyubarsky,Valder R. Arruda,Barbara A. Konkle,Edwin M. Stone,Edwin M. Stone,Junwei Sun,Jonathan B. Jacobs,L. F. Dell'Osso,Richard W. Hertle,Jian Xing Ma,T. Michael Redmond,Xiaosong Zhu,Bernd Hauck,Olga Zelenaia,Kenneth S. Shindler,Maureen G. Maguire,J. Fraser Wright,Nicholas J. Volpe,Jennifer Wellman McDonnell,Alberto Auricchio,Katherine A. High,Katherine A. High,Jean Bennett +33 more
TL;DR: This study investigated the safety of subretinal delivery of a recombinant adeno-associated virus (AAV) carrying RPE65 complementary DNA (cDNA) and found three patients with LCA2 had an acceptable local and systemic adverse-event profile after delivery of AAV2.hRPE65v2.
Journal ArticleDOI
Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial
Albert M. Maguire,Albert M. Maguire,Katherine A. High,Katherine A. High,Alberto Auricchio,J. Fraser Wright,J. Fraser Wright,Eric A. Pierce,Eric A. Pierce,Francesco Testa,Federico Mingozzi,Jeannette L. Bennicelli,Gui-Shuang Ying,Settimio Rossi,Ann Fulton,Kathleen A. Marshall,Sandro Banfi,Daniel C. Chung,Jessica I. W. Morgan,Bernd Hauck,Olga Zelenaia,Xiaosong Zhu,Leslie Raffini,Frauke Coppieters,Elfride De Baere,Kenneth S. Shindler,Nicholas J. Volpe,Enrico Maria Surace,Carmela Acerra,Arkady Lyubarsky,T. Michael Redmond,T. Michael Redmond,Edwin M. Stone,Edwin M. Stone,Junwei Sun,Jenni Fer Uvellman Mcdonnell,Bart P. Leroy,Bart P. Leroy,Francesca Simonelli,Jean Bennett,Jean Bennett +40 more
TL;DR: The safety, extent, and stability of improvement in vision in all patients support the use of AAV-mediated gene therapy for treatment of inherited retinal diseases, with early intervention resulting in the best potential gain.
Journal ArticleDOI
Relation of Visual Function to Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis
Jennifer B. Fisher,Dina A. Jacobs,Clyde E. Markowitz,Steven L. Galetta,Nicholas J. Volpe,M. Ligia Nano-Schiavi,Monika Baier,Elliot M. Frohman,Heather Winslow,Teresa C. Frohman,Peter A. Calabresi,Maureen G. Maguire,Gary Cutter,Laura J. Balcer +13 more
TL;DR: Scores for low-contrast letter acuity and contrast sensitivity correlate well with RNFL thickness as a structural biomarker, supporting validity for these visual function tests as secondary clinical outcome measures for MS trials.
Journal ArticleDOI
Profiles of Obesity, Weight Gain, and Quality of Life in Idiopathic Intracranial Hypertension (Pseudotumor Cerebri)
Anthony B. Daniels,Grant T. Liu,Nicholas J. Volpe,Steven Galetta,Mark L. Moster,Nancy J. Newman,Valérie Biousse,Andrew G. Lee,Michael Wall,Randy H. Kardon,Marie D. Acierno,James J. Corbett,Maureen G. Maguire,Laura J. Balcer +13 more
TL;DR: Higher levels of weight gain and BMI are associated with greater risk of idiopathic intracranial hypertension and vision-specific and overall HRQOL are affected to a greater extent in IIH than in other neuro-ophthalmologic disorders.
Journal ArticleDOI
Idiopathic intracranial hypertension: relation of age and obesity in children.
Laura J. Balcer,Grant T. Liu,S. Forman,K. Pun,Nicholas J. Volpe,Steven Galetta,Maureen G. Maguire +6 more
TL;DR: Twenty-three percent of patients aged 3 to 11 years were obese, whereas 81% of those in the 12- to 14-year age group and 91% of Those in the 15- to 17- year age group met criteria for obesity (p = 0.01).