L
L G M van Baarsen
Researcher at University of Amsterdam
Publications - 27
Citations - 942
L G M van Baarsen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Arthritis & Rheumatoid arthritis. The author has an hindex of 10, co-authored 24 publications receiving 850 citations. Previous affiliations of L G M van Baarsen include VU University Medical Center.
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Journal ArticleDOI
Rheumatoid Arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients
T C T M van der Pouw Kraan,Carla A. Wijbrandts,L G M van Baarsen,Alexandre E Voskuyl,François Rustenburg,J.M. Baggen,Saleh M. Ibrahim,Michael J. Fero,B A C Dijkmans,Paul P. Tak,Cornelis L. Verweij +10 more
TL;DR: The IFN type I signature defines a subgroup of patients with RA, with a distinct biomolecular phenotype, characterised by increased activity of the innate defence system, coagulation and complement cascades, and fatty acid metabolism.
Journal ArticleDOI
Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis
M J H de Hair,M. van de Sande,TH Ramwadhdoebe,Monika Hansson,Robert Landewé,C van der Leij,Mario Maas,Guy Serre,D. van Schaardenburg,Lars Klareskog,Danielle M. Gerlag,L G M van Baarsen,Paul P. Tak +12 more
TL;DR: Examination of the relationship between the presence of autoantibodies, changes in the synovium, and development of arthritis over time in a markedly larger, prospective study found that subclinical inflammation of thesynovium does not coincide with the appearance of rheumatoid arthritis.
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A subtype of multiple sclerosis defined by an activated immune defense program.
L G M van Baarsen,T C T M van der Pouw Kraan,J.J. Kragt,J.M. Baggen,François Rustenburg,T Hooper,J F Meilof,Mike Fero,Christine D. Dijkstra,Chris H. Polman,Cornelis L. Verweij +10 more
TL;DR: It is concluded that the transcriptional signature of the PB cells reflects the heterogeneity of MS and defines a sub-population of RRMS patients, who exhibit an activated immune defense program that resembles a virus response program, which is supportive for a link between viruses and MS.
Journal ArticleDOI
Responsiveness to anti-tumour necrosis factor alpha therapy is related to pre-treatment tissue inflammation levels in rheumatoid arthritis patients.
C.T.M. van der Pouw Kraan,Carla A. Wijbrandts,L G M van Baarsen,François Rustenburg,J.M. Baggen,Cornelis L. Verweij,Paul P. Tak +6 more
TL;DR: It is indicated that patients with a high level of tissue inflammation are more likely to benefit from anti-TNFα treatment, compared to those who did not show clinical improvement.
Journal ArticleDOI
Gene expression analysis in RA: towards personalized medicine
Agata Burska,K Roget,M Blits,L Soto Gomez,F van de Loo,Lee Hazelwood,Cornelis L. Verweij,Anthony Rowe,George N. Goulielmos,L G M van Baarsen,Frederique Ponchel +10 more
TL;DR: This review analyses currently available information with respect to RA diagnostic, prognostic and prediction of response to therapy with a view to highlight the abundance of data, whose comparison is often inconclusive due to the mixed use of material source, experimental methodologies and analysis tools.