L. Lyndon Key

TL;DR: Investigation of use of oral simvastatin in 30 individuals with relapsing-remitting multiple sclerosis found it to inhibit inflammatory components of multiple sclerosis that lead to neurological disability.

TL;DR: Long-term therapy with interferon gamma in patients with osteopetrosis increases bone resorption and hematopoiesis and improves leukocyte function.

TL;DR: Evidence strongly indicates that NADPH oxidase is an enzyme system responsible for superoxide generation in osteoclasts, and the cloning of a NAD PH oxidase subunit (Nox 4) with 578 amino acids is reported, explaining the normal resorptive activity seen in the osteoclast where no p91 is present.

TL;DR: This study suggests that AICAR inhibits adipocyte differentiation via downregulation of expression of adipogenic factors in vitro and reduces adipose tissue content in DIO mice by activating expression of PGC1α without inhibiting adipocyte-specific transcription factors in Dio mice.

TL;DR: The K diet can be used effectively for rapid weight loss in adolescents with morbid obesity and loss in lean body mass is blunted, blood chemistries remain normal, and sleep abnormalities significantly decrease with weight loss.