Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes

Effect of cadmium chloride on transepithelial electrical resistance of Sertoli cell monolayers in two-compartment cultures--a new model for toxicological investigations of the "blood-testis" barrier in vitro.

Effects of i.p. administered cadmium acetate (Cd, 0.4 mg/kg) was studied on the levels of vitamin E and ascorbic acid in different brain regions, liver, kidney, testis, RBC and plasma at 15, 30 and 60 days intervals in male albino rats (45 +/- 5 g). Exposure to Cd for 15 days decreased the levels of vitamin E significantly in the liver and testis only, while 30 days of treatment resulted in a significant decline in cerebellum, cerebral cortex, corpus striatum, mid-brain + hypothalamus, and plasma. Cadmium administration for 60 days caused a decrease in vitamin E in all tissues. Furthermore, a duration-dependent decrease in hepatic ascorbic acid levels was noticed. The implications of these results are discussed.

Cadmium toxicity and bioantioxidants: status of vitamin E and ascorbic acid of selected organs in rat.

Toxicity of cadmium chloride in vitro: Indices of cytotoxicity with the pulmonary alveolar macrophage

Accumulation of cadmium by the eye with special reference to the lens.

Effect of cadmium on epithelial membranes

Cadmium, 10(-3) mol/l on the mucosal or 10(-5) mol/l on the serosal side of the toad urinary bladder, inhibits the hydro-osmotic effect of vasopressin. This inhibition is irreversible. The osmotic transfer of water in the absence of vasopressin was unaffected by the presence of the Cd2+. The hydro-osmotic response to cyclic AMP was also reduced by the Cd2+, but the response due to hypertonicity of the serosal bathing solution was unaffected. The short-circuit current (reflecting active transmural Na+ transport) was inhibited by 10(-3) mol Cd2+/l on the serosa, but was increased by 10(-3) mol/l at the mucosa or 10(-4) mol/l at the serosa. The natriferic response of the bladder to vasopressin was unaffected when Cd2+ was present under conditions that inhibited the hydro-osmotic response, further emphasizing that separate effector mechamisms may be involved for each effect.

L.N. Fleisher

Papers

Effect of cadmium on epithelial membranes

Effects of cadmium on the hydro-osmotic and natriferic responses of the toad bladder to vasopressin