L
L Yan
Researcher at Yale University
Publications - 1
Citations - 181
L Yan is an academic researcher from Yale University. The author has contributed to research in topics: microRNA & Regulation of gene expression. The author has an hindex of 1, co-authored 1 publications receiving 162 citations.
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Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.
L Yan,Jichun Zhou,Y Gao,Sanaz Ghazal,Lingeng Lu,Stefania Bellone,Yang Yang,N Liu,Xinyang Zhao,Alessandro D. Santin,Hugh S. Taylor,Yingqun Huang +11 more
TL;DR: It is shown that H19 depletion impairs, whereas its overexpression enhances the motility and invasiveness of tumor cells, and that the anti-diabetic drug metformin inhibits tumor cell migration and invasion, partly by downregulating H19 via DNA methylation.