S
Stefania Bellone
Researcher at Yale University
Publications - 132
Citations - 4594
Stefania Bellone is an academic researcher from Yale University. The author has contributed to research in topics: HER2/neu & Uterine serous carcinoma. The author has an hindex of 33, co-authored 112 publications receiving 3391 citations.
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Journal ArticleDOI
Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That Overexpress Human Epidermal Growth Factor Receptor 2/neu
Amanda N. Fader,Dana M. Roque,Eric R. Siegel,Natalia Buza,Pei Hui,Osama Abdelghany,Setsuko K. Chambers,Angeles Alvarez Secord,Laura J. Havrilesky,David M. O'Malley,Floor J. Backes,Nicole S. Nevadunsky,Babak Edraki,Dirk Pikaart,William J. Lowery,K. ElSahwi,Paul Celano,Stefania Bellone,Masoud Azodi,Babak Litkouhi,Elena Ratner,Dan-Arin Silasi,Peter E. Schwartz,Alessandro D. Santin +23 more
TL;DR: Addition of trastuzumab to carboplatin-paclitaxel was well tolerated and increased progression-free survival, and no unexpected safety signals emerged.
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Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.
Siming Zhao,Murim Choi,John D. Overton,Stefania Bellone,Dana M. Roque,Emiliano Cocco,Federica Guzzo,Diana P. English,Joyce Varughese,Sara Gasparrini,Ileana Bortolomai,Natalia Buza,Pei Hui,Maysa M. Abu-Khalaf,Antonella Ravaggi,Eliana Bignotti,Elisabetta Bandiera,Chiara Romani,Paola Todeschini,Renata A. Tassi,Laura Zanotti,Luisa Carrara,Sergio Pecorelli,Dan-Arin Silasi,Elena Ratner,Masoud Azodi,Peter E. Schwartz,Thomas J. Rutherford,Amy L. Stiegler,Shrikant Mane,Titus J. Boggon,Joseph Schlessinger,Richard P. Lifton,Alessandro D. Santin +33 more
TL;DR: Analysis of whole-exome sequencing of 57 cancers identified frequent mutation of DNA damage, chromatin remodeling, cell cycle, and cell proliferation pathways in USC and suggest potential targets for treatment of this lethal variant of endometrial cancer.
Journal ArticleDOI
Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer
Mingzhu Yin,Xia Li,Shu Tan,Huanjiao Jenny Zhou,Weidong Ji,Stefania Bellone,Xiaocao Xu,Haifeng Zhang,Alessandro D. Santin,Ge Lou,Wang Min +10 more
TL;DR: It is determined that TAMs promote spheroid formation and tumor growth at early stages of transcoelomic metastasis in an established mouse model for epithelial ovarian cancer.
Journal ArticleDOI
Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.
L Yan,Jichun Zhou,Y Gao,Sanaz Ghazal,Lingeng Lu,Stefania Bellone,Yang Yang,N Liu,Xinyang Zhao,Alessandro D. Santin,Hugh S. Taylor,Yingqun Huang +11 more
TL;DR: It is shown that H19 depletion impairs, whereas its overexpression enhances the motility and invasiveness of tumor cells, and that the anti-diabetic drug metformin inhibits tumor cell migration and invasion, partly by downregulating H19 via DNA methylation.
Journal ArticleDOI
Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu
TL;DR: To study the effect of trastuzumab in patients with progressive or recurrent metastatic endometrial carcinoma shown by immunohistochemistry to overexpress the HER2/neu receptor.