1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.

The survival rate, p , of a measured inoculum of Staph. aureus in a standard volume of denbrinated blood, is a reliable quantitative measure of the bactericidal power of blood. The number of viable organisms in the inoculum and in the blood-bacterium mixture may be estimated with the necessary accuracy by counts of colonies developing from measured volumes of the fluids let fall on to the surface of solid media. Fildes' agar was the most suitable medium for this surface-viable count, and was selected on the basis of four criteria; of the media tested it yielded the highest counts, and the counts conformed most closely to a Poisson series; and on it the mean colony size was maximum, and the coefficient of variation of colony size was minimum. On this medium, the close conformity of the separate count values to a Poisson series enabled the standard error of the survival rate to be determined from a simplification of the general expression for the standard error of a ratio. The number of colonies growing from a sample of a blood-bacterium mixture may be reduced, not by killing of the individual cocci, but as a result of their aggregation either by agglutinins in the blood, or in the cytoplasm of leucocytes that are phagocytic but not bactericidal. It appears that these mechanisms are unlikely to operate in blood-bacterium mixture containing relatively few organisms; in such mixtures the survival rate is a reflexion of the killing power only. The immunological significance of p has not been investigated, but the range of values for healthy human adults differs significantly from that for sufferers from chronic staphylococcal infection. Moreover, by the technique employed differences may be detected between individual values of p that cannot reasonably be attributed to technical or sampling errors.

The Estimation of the Bactericidal Power of the Blood. With a Note by J. O. IRWIN.

Tetrazole hybrids with potential anticancer activity.

Current scenario of tetrazole hybrids for antibacterial activity.

This research presents a novel biological route for the biosynthesis of nickel oxide nanoparticles (NiO NPs) using marine macroalgae extract as a reducing and coating agent under optimized synthesis conditions. XRD and TEM analyses revealed that phytosynthesized NiO NPs are crystalline in nature with a spherical shape having a mean particle size of 32.64 nm. TGA results indicated the presence of marine-derived organic constituents on the surface of NiO NPs. It is found that biogenic NiO NPs with BET surface area of 45.59 m2g−1 is a highly efficient catalyst for benign one-pot preparation of pyridopyrimidine derivatives using aqueous reaction conditions. This environmentally friendly procedure takes considerable advantages of shorter reaction times, excellent product yields (up to 96%), magnetically viable nanocatalyst (7 runs), low catalyst loadings, and free toxic chemical reagents.

/pdf/algal-magnetic-nickel-oxide-nanocatalyst-in-accelerated-39v5wn8rzz.pdf

Algal magnetic nickel oxide nanocatalyst in accelerated synthesis of pyridopyrimidine derivatives.

PEG-400 mediated an efficient eco-friendly synthesis of new isoxazolyl pyrido[2,3-d]pyrimidines and their anti-inflammatory and analgesic activity

The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.

Process for the preparation of tenofovir disoproxil fumarate

Retracted: Design, Synthesis and Molecular Modeling of Nonsteroidal Anti-inflammatory Drugs Tagged Substituted 1,2,3-Triazole Derivatives and Evaluation of Their Biological Activities

Water‐PEG‐400 Mediated an Efficient One‐Pot Eco‐Friendly Synthesis of Functionalized Isoxazole Substituted Chromeno[2, 3‐b]pyridine‐3‐carboxylate Derivatives

Lakshmana Rao Vadali

Papers

PEG-400 mediated an efficient eco-friendly synthesis of new isoxazolyl pyrido[2,3-d]pyrimidines and their anti-inflammatory and analgesic activity

Process for the preparation of tenofovir disoproxil fumarate

Retracted: Design, Synthesis and Molecular Modeling of Nonsteroidal Anti-inflammatory Drugs Tagged Substituted 1,2,3-Triazole Derivatives and Evaluation of Their Biological Activities

Water‐PEG‐400 Mediated an Efficient One‐Pot Eco‐Friendly Synthesis of Functionalized Isoxazole Substituted Chromeno[2, 3‐b]pyridine‐3‐carboxylate Derivatives

Retracted: Synthesis, Molecular Properties, and Biological Evaluation of Hybrid 1,2,3-Triazolylpolyaza Heterocyclic Compounds