L
Lance Wells
Researcher at University of Georgia
Publications - 173
Citations - 11793
Lance Wells is an academic researcher from University of Georgia. The author has contributed to research in topics: Glycosylation & Glycan. The author has an hindex of 52, co-authored 165 publications receiving 10495 citations. Previous affiliations of Lance Wells include Johns Hopkins University & University of California, Davis.
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Book ChapterDOI
Approaches for site mapping and quantification of O-linked glycopeptides.
TL;DR: This chapter refers to several approaches for the structural characterization and quantification of O-linked glycopeptides, with a focus on O-GlcNAc and O-Mannose modified glycoproteins.
Journal ArticleDOI
Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.
TL;DR: Results strongly suggest that the defect in insulin action upon PUGNAc treatment does not derive from its inhibition of OGA or HexA/B, and that there is an unknown target of PugNAc that is the likely culprit in inhibiting the protective effect of insulin from apoptosis.
Journal ArticleDOI
Trypanosoma cruzi 13C-labeled O-Glycan standards for mass spectrometry.
M. Osman Sheikh,Elisabet Gas-Pascual,John Glushka,Juan M. Bustamante,Lance Wells,Christopher M. West +5 more
TL;DR: Five synthetic O-glycan analytical standards are described and show their potential to enable a more facile analysis of native O- glycan isomers based on mass spectrometry.
Reference EntryDOI
Quantitative Glycomics of Cultured Cells Using Isotopic Detection of Aminosugars with Glutamine (IDAWG).
TL;DR: Detailed procedures are provided for glycan analysis using IDAWG including labeling, release of both N- and O-linked glycans, permethylation, and mass spectrometry analysis.
Journal ArticleDOI
A terminal α3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii
Msano Mandalasi,Hyun W. Kim,David F. Thieker,M. Osman Sheikh,Elisabet Gas-Pascual,Kazi Rahman,Peng Zhao,Nitin G. Daniel,Hanke van der Wel,H. Travis Ichikawa,John Glushka,Lance Wells,Robert J. Woods,Zachary A. Wood,Christopher M. West +14 more
TL;DR: The substitution of glycosyltransferases in Toxoplasma and Pythium by an unrelated bifunctional enzyme that assembles a distinct but structurally compatible glycan in Dictyostelium is a remarkable case of convergent evolution, which emphasizes the importance of the terminal α-galactose and establishes the phylogenetic breadth of Skp1 glycoregulation.