C
Christopher M. West
Researcher at University of Georgia
Publications - 62
Citations - 1646
Christopher M. West is an academic researcher from University of Georgia. The author has contributed to research in topics: Glycosylation & Skp1. The author has an hindex of 21, co-authored 58 publications receiving 1470 citations. Previous affiliations of Christopher M. West include University of Oklahoma Health Sciences Center & University of Oklahoma.
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Journal ArticleDOI
Golgi duplication in Trypanosoma brucei
Cynthia Y. He,Helen H. Ho,Joerg Malsam,Cecile Chalouni,Christopher M. West,Elisabetta Ullu,Derek Toomre,Graham Warren +7 more
TL;DR: Photobleaching experiments show that the new Golgi is not the exclusive product of the new ER export site, rather, it is supplied, at least in part, by material directly from the old Golgi.
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Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
Richard Sucgang,Alan Kuo,Xiangjun Tian,William J Salerno,Anup Parikh,Christa L. Feasley,Eileen Dalin,Hank Tu,Eryong Huang,Kerrie Barry,Erika Lindquist,Harris Shapiro,David G Bruce,Jeremy Schmutz,Asaf Salamov,Petra Fey,Pascale Gaudet,Christophe Anjard,M. Madan Babu,S. Basu,Yulia A. Bushmanova,Hanke van der Wel,Mariko Katoh-Kurasawa,Christopher Dinh,Pedro M. Coutinho,Tamao Saito,Marek Eliáš,Pauline Schaap,Robert R. Kay,Bernard Henrissat,Ludwig Eichinger,Francisco Rivero,Nicholas H. Putnam,Christopher M. West,William F. Loomis,Rex L. Chisholm,Gad Shaulsky,Gad Shaulsky,Joan E. Strassmann,David C. Queller,Adam Kuspa,Adam Kuspa,Igor V. Grigoriev +42 more
TL;DR: Genes involved in the social stage evolved more rapidly than others, consistent with either relaxed selection or accelerated evolution due to social conflict, and shed light on the biology and evolution of the Dictyostelia.
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O-GlcNAc protein modification in plants: Evolution and function
TL;DR: The phenotypes of sec and spy single and double mutants indicate that O-GlcNAc modification is essential and that it affects diverse plant processes including response to hormones and environmental signals, circadian rhythms, development, intercellular transport and virus infection.
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Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice
Kirk Bergstrom,Xiaowei Liu,Yiming Zhao,Yiming Zhao,Nan Gao,Nan Gao,Qian Wu,Qian Wu,Kai Song,Yi Cui,Yun Li,Yun Li,J. Michael McDaniel,Samuel McGee,Weichang Chen,Mark M. Huycke,Mark M. Huycke,Courtney W. Houchen,Lauren A. Zenewicz,Christopher M. West,Hong Chen,Jonathan Braun,Jianxin Fu,Jianxin Fu,Lijun Xia,Lijun Xia,Lijun Xia +26 more
TL;DR: Impaired expression of O-glycans causes colonic mucus barrier breach and subsequent microbiota-mediated activation of caspase 1-dependent inflammasomes in colonic epithelial cells of mice, which could contribute to colitis-associated colon cancer in humans.
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Prolyl 4-hydroxylase-1 mediates O2 signaling during development of Dictyostelium.
TL;DR: The evidence provides novel genetic support for the animal-derived O2-sensor model of prolyl 4-hydroxylase function, in an organism that lacks the canonical HIFα transcriptional factor subunit substrate target that is a feature of animal hypoxic signaling.