L
Larry J. Guilbert
Researcher at University of Alberta
Publications - 96
Citations - 9501
Larry J. Guilbert is an academic researcher from University of Alberta. The author has contributed to research in topics: Trophoblast & Cytokine. The author has an hindex of 45, co-authored 96 publications receiving 9173 citations. Previous affiliations of Larry J. Guilbert include St Mary's Hospital & Canadian Red Cross.
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Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
TL;DR: In this article, the authors hypothesize that TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens, since pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell mediated immunity.
Journal Article
Synthesis of T helper 2-type cytokines at the maternal-fetal interface.
TL;DR: The continuous presence of IL-4, IL-5, and IL-10, with early and transient expression of IFN-gamma, can provide a molecular basis for the antibody/Th2-like bias of the maternal immune response during pregnancy.
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Inflammatory processes in preterm and term parturition
Inge Christiaens,Dean B. Zaragoza,Larry J. Guilbert,Sarah A. Robertson,Bryan F. Mitchell,David M. Olson +5 more
TL;DR: All uterine tissues progress through a staged transformation near the end of pregnancy that leads from relative uterine quiescence and maintenance of pregnancy to the activation of the uterus that prepares it for the work of labour and production of stimulatory molecules that trigger the onset of labour
Journal Article
T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.
TL;DR: It is suggested that a beneficial anti-parasite Th1 response can adversely affect pregnancy outcome and Th1 cytokines may be deleterious for not only placental maintenance but also preimplantation events.
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Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts.
TL;DR: A physiological role of TNF-alpha and IFN-gamma expression in the placental villi may be to regulate the apoptotic death of villous cytotrophoblasts to predict potential harmful effects on placental development and function following aberrant inflammatory cytokine expression triggered by intravillous infections.