Showing papers in "Journal of Reproductive Immunology in 2008"

TL;DR: All uterine tissues progress through a staged transformation near the end of pregnancy that leads from relative uterine quiescence and maintenance of pregnancy to the activation of the uterus that prepares it for the work of labour and production of stimulatory molecules that trigger the onset of labour

TL;DR: Exosome concentrations correlated positively with the number of pregnancies, and heat shock protein-containing exosomes are constituents of mid-trimester amniotics fluids and may contribute to immune regulation within the amniotic cavity.

TL;DR: In this article, the authors focus on genital co-infections, which increase HIV levels in the genital secretions, thereby increasing secondary sexual transmission and have the potential to curb the pandemic.

TL;DR: The cytokine paradigm of NK cells in human pregnancy is discussed and how NK reg cells and cytotoxic NK cells affect the reproductive immune response is focused on.

TL;DR: Using a mouse model of APS induced by passive transfer of human aPL antibodies, it is shown that complement activation plays an essential and causative role in pregnancy loss and fetal growth restriction, and that blocking activation of the complement cascade rescues pregnancies.

TL;DR: Cytokine levels were detected in plasma during early- and mid-pregnancy, with IL-6, IL-12, IFN-gamma and GM-CSF concentrations varying over pregnancy, which may depend on BMI, maternal age and prior preterm delivery.

TL;DR: Although the tissues of origin of circulating cytokines are unclear, the observed elevations across many cytokines among women who later delivered <35 weeks with HCA may represent a robust immune response to infection within gestational tissues.

TL;DR: Recent information regarding the existence of TLRs in the female reproductive tract, their function in the maintenance of innate immune system in this tract and their potential role in pregnancy are reviewed.

TL;DR: It is demonstrated that, in pregnancy, the dendritic cell system is modified to favour type 2 T helper cell responses.

TL;DR: The hypothesis that high titers of antibodies and blocking of folic acid binding to FRs by maternal serum should be regarded as risk factors for NTDs is supported.

TL;DR: The use ofAnti-TNF-alpha decreased fetal deaths and preterm deliveries in an LPS-induced model of preterm birth and there were critical gene expression alterations in the group receiving anti-T NF-alpha.

TL;DR: The fetal HLA-G 14bp genotype is reflected in the decidual HLA -G mRNA splice form profile, but does not appear to be associated with increased risk for development of PE.

TL;DR: In this article, the occurrence of TNF-alpha, IL-6 and IL-10 polymorphisms is increased in women of a population with preeclampsia in a previous pregnancy.

TL;DR: The association between impairment in platelet responsiveness and higher levels of TGF-beta(1) in the plasma of patients with preeclampsia suggests that this cytokine may play a role in the pathophysiological events of preeclampedia that are dependent on platelet activation.

TL;DR: Increased leptin levels in peritoneal fluid from endometriosis patients may affect local inflammatory/immune reactions, especially infiltration of CD4+ T helper cells, and leptin may play an important role in the immunopathogenesis of endometRIosis.

TL;DR: A major role is underscore for PPARgamma and LXRbeta in the control of human trophoblast invasion and suggest that excess ligands such as oxidized LDLs at the implantation site might contribute to the development of preeclampsia.

TL;DR: Results from this study indicate, that low serum IL-18 level could be associated with PTD in women with symptoms of PTD, as the risk of delivering before 34 weeks is increased with the combination of low IL- 18 and high IL-12, but further studies are warranted.

TL;DR: The results indicate that chimerism can occur in normal organs of women without autoimmune disease, and there was no association between the presence of chimeric cells and blood transfusion history.

TL;DR: It is shown that Ym1 protein expression in the testis is dependent upon IL- 13R signaling, and that IL-13 is produced in theTesticular immune privilege by the maintenance of an alternatively activated macrophage population.

TL;DR: In this article, the ability of antibody (Ab) to modulate HSV pathogenesis is well recognized but the mechanisms by which HSV-specific IgG antibodies protect against genital HSV 2 disease are not well understood.

TL;DR: An association between C. albicans and levels of IL-8 in mucosal genital fluid is shown and regression analysis showed a positive association betweenIL-8 and Candida, and there was an inverse relationship between lactobacilli and IL-7.

TL;DR: These studies show that soluble factor(s) present in the lower genital tract of women with BV activate cells via TLR2, identifying a pathway through which BV may mediate adverse effects.

TL;DR: Evidence that PIBF is synthesized in the human placenta and determine its cellular source is presented; its tissue distribution suggests a role both in systemic and local (decidual) immunoregulation.

TL;DR: Ethnic differences in cytokine concentrations were also observed in women with normal flora, indicating that white and black women withnormal flora have different cytokine levels, but respond to BV in a similar manner.

TL;DR: Evidence is provided that MIF directly up-regulates alphavbeta3 integrin and VEGF expression in human endometrial Ishikawa cells and may advance the understanding of factors involved in the establishment of endometrian receptivity and successful implantation.

TL;DR: GCP-2/CXCL6 in seminal plasma may play roles in both host defense of the male urogenital tract and during fertilization, as determined by immunohistochemistry.

TL;DR: The data suggest that a shift in T(H)1/T( H)2 cytokine production does not occur in pregnant sheep and indicate that further comparative reproductive immunology studies on species with non-invasive placentation will be informative of materno-fetal interactions and immune regulation during pregnancy.

TL;DR: The production of TNF by monocytes stimulated with TLR ligands was significantly impaired in PE, whereas IL-10 production was not affected, suggesting the imbalance between an inflammatory and anti-inflammatory pattern of monocytes may play a role in PE pathophysiology.

TL;DR: These studies document generation of MAbs exhibiting high specificity for human zona proteins, which will be useful reagents to study their immunobiology.

TL;DR: The creation of mice with conditional deletion of SOCS3 in different tissues has uncovered critical roles for SOCS 3 in the regulation of IL-6, G-CSF and leptin signalling and highlights the role of LIF as an extrinsic factor regulating trophoblast differentiation in vivo.