L
Lars Østergaard Pedersen
Researcher at Lundbeck
Publications - 90
Citations - 4391
Lars Østergaard Pedersen is an academic researcher from Lundbeck. The author has contributed to research in topics: MHC class I & Major histocompatibility complex. The author has an hindex of 32, co-authored 89 publications receiving 4101 citations. Previous affiliations of Lars Østergaard Pedersen include Nielsen Holdings N.V. & University of Copenhagen.
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Journal ArticleDOI
Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
Marcel Leist,Pietro Ghezzi,Giovanni Grasso,Giovanni Grasso,Roberto Bianchi,Pia Villa,Maddalena Fratelli,Costanza Savino,Marina Bianchi,Jacob Nielsen,Jens Gerwien,Pekka Kallunki,Anna Kirstine Larsen,Lone Helboe,Søren Christensen,Lars Østergaard Pedersen,Mette Nielsen,Lars Torup,Thomas N. Sager,Alessandra Sfacteria,Alessandra Sfacteria,Serhat Erbayraktar,Serhat Erbayraktar,Zübeyde Erbayraktar,Zübeyde Erbayraktar,Necati Gokmen,Osman Yilmaz,Osman Yilmaz,Carla Cerami-Hand,Qiao-Wen Xie,Thomas Coleman,Anthony Cerami,Michael Brines +32 more
TL;DR: CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.
Journal ArticleDOI
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.
Serhat Erbayraktar,Giovanni Grasso,Giovanni Grasso,Alessandra Sfacteria,Alessandra Sfacteria,Qiao wen Xie,Thomas Coleman,Mads Kreilgaard,Lars Torup,Thomas N. Sager,Zübeyde Erbayraktar,Zübeyde Erbayraktar,Necati Gokmen,Osman Yilmaz,Pietro Ghezzi,Pietro Ghezzi,Pia Villa,Maddalena Fratelli,Simona Casagrande,Marcel Leist,Lone Helboe,Jens Gerwein,Søren Christensen,Marie Aavang Geist,Lars Østergaard Pedersen,Carla Cerami-Hand,Jean Paul Wuerth,Anthony Cerami,Michael Brines +28 more
TL;DR: Asialoerythropoietic variants of rhEPO can cross the blood–brain barrier and provide neuroprotection, and asialoEPO exhibits a broad spectrum of neuroprotective activities, as demonstrated in models of cerebral ischemia, spinal cord compression, and sciatic nerve crush.
Journal Article
Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients
Mads Hald Andersen,Lars Østergaard Pedersen,Barbara Capeller,Eva-Bettina Bröcker,Jürgen C. Becker,Per thor Straten +5 more
TL;DR: Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T- cell epitopes in breast cancer, leukemia, and melanoma patients both in situ as well as ex vivo are demonstrated.
Journal Article
Identification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein survivin in cancer patients
TL;DR: Specific T-cell reactivity against survivin-deduced peptide epitopes is described in peripheral blood from chronic lymphatic leukemia patients and in tumor-infiltrated lymph nodes from melanoma patients by ELISPOT analysis.
Journal ArticleDOI
T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides.
TL;DR: The NH2-terminal end of the longer peptide could, even while bound to major histocompatibility complex (MHC) class II molecules, be digested by APN with dramatic consequences for T cell antigen recognition, and MHC class II and APN may act in concert to generate the final T cell epitopes.